Key features and details
- Rabbit polyclonal to Activin A Receptor Type IB/ALK-4
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-Activin A Receptor Type IB/ALK-4 antibody
See all Activin A Receptor Type IB/ALK-4 primary antibodies
DescriptionRabbit polyclonal to Activin A Receptor Type IB/ALK-4
SpecificityAt least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Human
Synthetic peptide corresponding to Human Activin A Receptor Type IB/ALK-4 (C terminal). ACVR1B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human ACVR1B.
Database link: P36896
- Human kidney tissue lysate
Antibodies should not be exposed to prolonged high temperatures.
Previously labelled as Activin A Receptor Type IB.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. Please see notes section.
Storage bufferPreservative: 0.02% Sodium azide
Constituent: 99.98% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab77049 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa.|
FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
Tissue specificityExpressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
- Information by UniProt
FormThere are 3 isoforms produced by alternative splicing. Isoform 1 also known as SKR2-1; isoform 2 as SKR2-2; isoform 3 as SKR2-3.
- Activin A receptor type 1B antibody
- Activin A receptor type II like kinase 4 antibody
- Activin A type 1B receptor antibody
All lanes : Anti-Activin A Receptor Type IB/ALK-4 antibody (ab77049) at 1 µg/ml
Lane 1 : human kidney tissue lysate
Lane 2 : human kidney tissue lysate with blocking peptide
Lysates/proteins at 15 µg per lane.
Predicted band size: 57 kDa
Observed band size: 66 kDa why is the actual band size different from the predicted?
ab77049 has been referenced in 1 publication.
- Colas AR et al. Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. Genes Dev 26:2567-79 (2012). PubMed: 23152446