Overview

  • Product name

    Anti-Activin A Receptor Type IB/ALK-4 antibody
    See all Activin A Receptor Type IB/ALK-4 primary antibodies
  • Description

    Rabbit polyclonal to Activin A Receptor Type IB/ALK-4
  • Host species

    Rabbit
  • Specificity

    At least three isoforms of ACVR1B are known to exist. This antibody is predicted to have no cross-reactivity to ACVR1 or ACVR1C.
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide corresponding to Human Activin A Receptor Type IB/ALK-4 (C terminal). ACVR1B antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of the human ACVR1B.
    Database link: P36896

  • Positive control

    • Human kidney tissue lysate
  • General notes

    Antibodies should not be exposed to prolonged high temperatures.

    Previously labelled as Activin A Receptor Type IB. 

Properties

Applications

Our Abpromise guarantee covers the use of ab77049 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 57 kDa.

Target

  • Function

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
  • Tissue specificity

    Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
  • Sequence similarities

    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Autophosphorylated.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Form

    There are 3 isoforms produced by alternative splicing. Isoform 1 also known as SKR2-1; isoform 2 as SKR2-2; isoform 3 as SKR2-3.
  • Alternative names

    • Activin A receptor type 1B antibody
    • Activin A receptor type II like kinase 4 antibody
    • Activin A type 1B receptor antibody
    • Activin A type IB receptor antibody
    • Activin receptor like kinase 4 antibody
    • Activin receptor type 1B antibody
    • Activin receptor type IB antibody
    • Activin receptor type-1B antibody
    • Activin receptor-like kinase 4 antibody
    • ACTR IB antibody
    • ACTR-IB antibody
    • ACTRIB antibody
    • ACV1B_HUMAN antibody
    • ACVR 1B antibody
    • Acvr1b antibody
    • ACVRLK 4 antibody
    • ACVRLK4 antibody
    • ALK 4 antibody
    • ALK-4 antibody
    • ALK4 antibody
    • Serine(threonine) protein kinase receptor R2 antibody
    • Serine/threonine-protein kinase receptor R2 antibody
    • SKR 2 antibody
    • SKR2 antibody
    see all

Images

  • All lanes : Anti-Activin A Receptor Type IB/ALK-4 antibody (ab77049) at 1 µg/ml

    Lane 1 : human kidney tissue lysate
    Lane 2 : human kidney tissue lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 57 kDa
    Observed band size: 66 kDa
    why is the actual band size different from the predicted?

References

This product has been referenced in:

  • Colas AR  et al. Whole-genome microRNA screening identifies let-7 and mir-18 as regulators of germ layer formation during early embryogenesis. Genes Dev 26:2567-79 (2012). Read more (PubMed: 23152446) »
See 1 Publication for this product

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