Overview

  • Product name

    Anti-Activin A Receptor Type IB/ALK-4 antibody [MM0054-11A7]
    See all Activin A Receptor Type IB/ALK-4 primary antibodies
  • Description

    Mouse monoclonal [MM0054-11A7] to Activin A Receptor Type IB/ALK-4
  • Host species

    Mouse
  • Specificity

    ab78415 detects Activin A Receptor Type IB (ALK4). No cross reactivity was found to Activin A Receptor Type IA (ALK2).
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Activin A Receptor Type IB/ALK-4 (extracellular).

  • General notes


    This antibody was produced from a hybridoma (mouse myeloma) fused with spleen cells from an immunized mouse.

    Previously labelled as Activin A Receptor Type IB. 

Properties

Applications

Our Abpromise guarantee covers the use of ab78415 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/1000. Predicted molecular weight: 57 kDa.
IHC-P 1/50.

Target

  • Function

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Phosphorylates TDP2.
  • Tissue specificity

    Expressed in many tissues, most strongly in kidney, pancreas, brain, lung, and liver.
  • Sequence similarities

    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 GS domain.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Autophosphorylated.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Form

    There are 3 isoforms produced by alternative splicing. Isoform 1 also known as SKR2-1; isoform 2 as SKR2-2; isoform 3 as SKR2-3.
  • Alternative names

    • Activin A receptor type 1B antibody
    • Activin A receptor type II like kinase 4 antibody
    • Activin A type 1B receptor antibody
    • Activin A type IB receptor antibody
    • Activin receptor like kinase 4 antibody
    • Activin receptor type 1B antibody
    • Activin receptor type IB antibody
    • Activin receptor type-1B antibody
    • Activin receptor-like kinase 4 antibody
    • ACTR IB antibody
    • ACTR-IB antibody
    • ACTRIB antibody
    • ACV1B_HUMAN antibody
    • ACVR 1B antibody
    • Acvr1b antibody
    • ACVRLK 4 antibody
    • ACVRLK4 antibody
    • ALK 4 antibody
    • ALK-4 antibody
    • ALK4 antibody
    • Serine(threonine) protein kinase receptor R2 antibody
    • Serine/threonine-protein kinase receptor R2 antibody
    • SKR 2 antibody
    • SKR2 antibody
    see all

Images

  • ab78415 at 1/50 dilution, staining Activin A Receptor Type IB/ALK-4 in human placental tissue section by Immunohistochemistry (Formalin/PFA fixed paraffin-embedded sections).

References

This product has been referenced in:

  • Tengroth L  et al. Activation of Activin receptor-like kinases curbs mucosal inflammation and proliferation in chronic rhinosinusitis with nasal polyps. Sci Rep 8:1561 (2018). Read more (PubMed: 29367682) »
See 1 Publication for this product

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