Anti-Activin Receptor Type IA antibody (ab115301)
Key features and details
- Goat polyclonal to Activin Receptor Type IA
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Activin Receptor Type IA antibody
See all Activin Receptor Type IA primary antibodies -
Description
Goat polyclonal to Activin Receptor Type IA -
Host species
Goat -
Tested applications
Suitable for: WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Goat, Horse, Cow, Dog, Pig -
Immunogen
Synthetic peptide:
C-RKFKRRNQERLNPRD
, corresponding to internal sequence amino acids 147-161 of Human Activin Receptor Type IA. -
Positive control
- Human Testis tissue; Human Umbilical Cord lysate
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab115301 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 57 kDa.
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IHC-P |
Use a concentration of 4 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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Notes |
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WB
Use a concentration of 0.3 - 1 µg/ml. Predicted molecular weight: 57 kDa. |
IHC-P
Use a concentration of 4 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
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Function
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. -
Tissue specificity
Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. -
Involvement in disease
Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible. -
Sequence similarities
Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 90 Human
- Entrez Gene: 11477 Mouse
- Entrez Gene: 79558 Rat
- Omim: 102576 Human
- SwissProt: Q28041 Cow
- SwissProt: Q04771 Human
- SwissProt: P37172 Mouse
- SwissProt: P80201 Rat
see all -
Alternative names
- Activin A receptor type I antibody
- Activin A receptor type II like kinase 2 antibody
- Activin receptor type I antibody
see all
Images
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ab115301, at 4 µg/ml, staining Activin Receptor Type IA in formalin-fixed, paraffin-embedded Human Testis by Immunohistochemistry, using a biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.
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Anti-Activin Receptor Type IA antibody (ab115301) at 0.3 µg/ml + Human Umbilical Cord lysate (in RIPA buffer) at 35 µg
Developed using the ECL technique.
Predicted band size: 57 kDa
Primary incubation was 1 hour.
Protocols
Datasheets and documents
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Datasheet download
References (0)
ab115301 has not yet been referenced specifically in any publications.