Key features and details
- Rabbit polyclonal to Activin Receptor Type IA
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Activin Receptor Type IA antibody
See all Activin Receptor Type IA primary antibodies
DescriptionRabbit polyclonal to Activin Receptor Type IA
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
KLH conjugated synthetic peptide from the central region of human Activin Receptor Type IA.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. Store In the Dark.
Storage bufferPreservative: 0.09% Sodium azide
Concentration information loading...
PurityAmmonium Sulphate Precipitation
Purification notesPrepared by Saturated Ammonium Sulfate (SAS) precipitation, followed by dialysis against PBS.
Our Abpromise guarantee covers the use of ab60157 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/100.|
FunctionOn ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.
Tissue specificityExpressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
Involvement in diseaseDefects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.
Sequence similaritiesBelongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
Contains 1 GS domain.
Contains 1 protein kinase domain.
- Information by UniProt
- Activin A receptor type I antibody
- Activin A receptor type II like kinase 2 antibody
- Activin receptor type I antibody
ab60157 has been referenced in 4 publications.
- Lees-Shepard JB et al. Activin-dependent signaling in fibro/adipogenic progenitors causes fibrodysplasia ossificans progressiva. Nat Commun 9:471 (2018). PubMed: 29396429
- Beraldo FH et al. Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex. J Neurochem 145:68-79 (2018). PubMed: 29265373
- De Vilder EYG et al. Pathogenic variants in the ABCC6 gene are associated with an increased risk for ischemic stroke. Brain Pathol 28:822-831 (2018). PubMed: 29722917
- Townsend KL et al. Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB J 26:2187-96 (2012). ICC/IF ; Mouse . PubMed: 22331196