Overview

  • Product name

    Anti-Activin Receptor Type IA antibody
    See all Activin Receptor Type IA primary antibodies
  • Description

    Goat polyclonal to Activin Receptor Type IA
  • Host species

    Goat
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Dog
  • Immunogen

    Synthetic peptide:

    C-RKFKRRNQERLNPRD

    , corresponding to internal sequence amino acids 147-161 of Human Activin Receptor Type IA, according to NP_001096.1.

  • Positive control

    • Human Umbilical Cord lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab66924 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: Use at a concentration of 0.3 - 1.0 µg/ml. Detects a band of approximately 60 kDa (predicted molecular weight: 57 kDa).
    Peptide ELISA: antibody detection limit dilution 1/128,000.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis.
    • Tissue specificity

      Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
    • Involvement in disease

      Defects in ACVR1 are a cause of fibrodysplasia ossificans progressiva (FOP) [MIM:135100]. FOP is a rare autosomal dominant disorder of skeletal malformations and progressive extraskeletal ossification. Heterotopic ossification in FOP begins in childhood and can be induced by trauma or may occur without warning. Bone formation is episodic and progressive, leading to extra-articular ankylosis of all major joints of the axial and appendicular skeleton, rendering movement impossible.
    • Sequence similarities

      Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
      Contains 1 GS domain.
      Contains 1 protein kinase domain.
    • Cellular localization

      Membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • Activin A receptor type I antibody
      • Activin A receptor type II like kinase 2 antibody
      • Activin receptor type I antibody
      • Activin receptor type-1 antibody
      • Activin receptor-like kinase 2 antibody
      • ACTR-I antibody
      • ACTRI antibody
      • Acvr1 antibody
      • ACVR1_HUMAN antibody
      • ACVR1A antibody
      • ACVRLK2 antibody
      • ALK 2 antibody
      • ALK-2 antibody
      • ALK2 antibody
      • FOP antibody
      • Hydroxyalkyl protein kinase antibody
      • Serine/threonine-protein kinase receptor R1 antibody
      • SKR1 antibody
      • TGF-B superfamily receptor type I antibody
      • TGFB superfamily receptor type I antibody
      • TSR-I antibody
      • TSRI antibody
      see all

    Images

    References

    ab66924 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    Application
    Western blot
    Sample
    Rat Tissue lysate - whole (rat aorta)
    Loading amount
    40 µg
    Specification
    rat aorta
    Gel Running Conditions
    Reduced Denaturing (9% SDS-PAGE)
    Blocking step
    BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C

    Dr. Chrispina Hong

    Verified customer

    Submitted Jan 25 2013

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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