Overview

  • Product name

    Anti-Activin Receptor Type IIA/ACVR2A antibody
    See all Activin Receptor Type IIA/ACVR2A primary antibodies
  • Description

    Rabbit polyclonal to Activin Receptor Type IIA/ACVR2A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide within Human Activin Receptor Type IIA/ACVR2A aa 20-70 (extracellular) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: P27037

  • Positive control

    • WB: Mouse testis and mouse brain lysates; IHC-P: rat brain tissue.
  • General notes

     This product was previously labelled as Activin Receptor Type IIA

     

Properties

Applications

Our Abpromise guarantee covers the use of ab216960 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/300 - 1/1000. Predicted molecular weight: 58 kDa.
IHC-P 1/200 - 1/400.

Target

  • Function

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
  • Sequence similarities

    Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.
    Contains 1 protein kinase domain.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Activin A receptor type IIA antibody
    • Activin receptor type 2A antibody
    • Activin receptor type IIA antibody
    • Activin receptor type-2A antibody
    • ACTR 2 antibody
    • ACTR IIA antibody
    • ACTR-IIA antibody
    • ACTR2 antibody
    • ACTRII antibody
    • ACTRIIA antibody
    • Acvr 2 antibody
    • Acvr 2A antibody
    • Acvr2 antibody
    • ACVR2A antibody
    • AVR2A_HUMAN antibody
    • OTTHUMP00000197918 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling Activin Receptor Type IIA/ACVR2A with ab216960 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

  • All lanes : Anti-Activin Receptor Type IIA/ACVR2A antibody (ab216960) at 1/200 dilution

    Lane 1 : mouse testis lysate
    Lane 2 : mouse brain lysate

    Secondary
    Lane 1 : HRP-conjugated secondary antibody at 1/3000 dilution
    Lane 2 : Goat Anti-Rabbit IgG Antibody (H+L), HRP conjugated, 90 min in 37°C at 1/3000 dilution

    Predicted band size: 58 kDa



    12% SDS-PAGE

References

ab216960 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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