Overview

  • Product name

    Acyclovir, viral DNA polymerase inhibitor
  • Description

    Inhibits viral DNA polymerase. Antiherpetic agent.
  • Biological description

    Guanosine derivative, competitively inhibits viral DNA polymerase. High specificity for herpes simplex 1 and 2 (EC50 values are 0.04 and 0.44 μM, respectively) and varicella-zoster viruses (IC50 = 0.22 μM).
  • Purity

    > 99%
  • CAS Number

    59277-89-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • De Clercq E & Field HJ Antiviral prodrugs - the development of successful prodrug strategies for antiviral chemotherapy. Br J Pharmacol 147:1-11 (2006). Read more (PubMed: 16284630) »
  • Suzuki M  et al. Synergistic antiviral activity of acyclovir and vidarabine against herpes simplex virus types 1 and 2 and varicella-zoster virus. Antiviral Res 72:157-61 (2006). Read more (PubMed: 16797734) »
  • Brand G  et al. The potency of acyclovir can be markedly different in different cell types. Life Sci 69:1285-90 (2001). Read more (PubMed: 11521752) »

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