Product nameAnti-ADA2 antibody
DescriptionRabbit polyclonal to ADA2
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Saccharomyces cerevisiae
Recombinant full length protein (His-tag) corresponding to Saccharomyces cerevisiae ADA2 aa 1-434. Recombinant protein produced in E. coli.
MSNKFHCDVCSADCTNRVRVSCAICPEYDLCVPCFSQGSYTGKHRPYHDY RIIETNSYPILCPDWGADEELQLIKGAQTLGLGNWQDIADHIGSRGKEEV KEHYLKYYLESKYYPIPDITQNIHVPQDEFLEQRRHRIESFRERPLEPPR KPMASVPSCHEVQGFMPGRLEFETEFENEAEGPVKDMVFEPDDQPLDIEL KFAILDIYNSRLTTRAEKKRLLFENHLMDYRKLQAIDKKRSKEAKELYNR IKPFARVMTAQDFEEFSKDILEELHCRARIQQLQEWRSNGLTTLEAGLKY ERDKQARISSFEKFGASTAASLSEGNSRYRSNSAHRSNAEYSQNYSENGG RKKNMTISDIQHAPDYALLSNDEQQLCIQLKILPKPYLVLKEVMFRELLK TGGNLSKSACRELLNIDPIKANRIYDFFQSQNWM
Database link: Q02336
- WB; whole cell extract of S. cerevisiae.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.1% Sodium azide
Our Abpromise guarantee covers the use of ab215524 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000.|
RelevanceFunctions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA, an altered form of SAGA, may be involved in positive transcriptional regulation. SLIK is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. ADA preferentially acetylates nucleosomal histones H3 (to form H3K14ac and H3K18ac) and H2B.
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ab215524 has not yet been referenced specifically in any publications.