Anti-ADAM17 antibody (ab2051)

Rabbit polyclonal ADAM17 antibody. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human. Cited in 36 publication(s). Independently reviewed in 9 review(s).

Publishing research using ab2051? Please let us know so that we can cite the reference in this datasheet.

ab2051 has been referenced in 36 publications.

  • Li Y  et al. ADAM17 promotes cell migration and invasion through the integrin ß1 pathway in hepatocellular carcinoma. Exp Cell Res 370:373-382 (2018). PubMed: 29966664
  • Siddharth S  et al. The soluble nectin-4 ecto-domain promotes breast cancer induced angiogenesis via endothelial Integrin-ß4. Int J Biochem Cell Biol 102:151-160 (2018). PubMed: 30056265
  • Chenxu G  et al. iRhom2 loss alleviates renal injury in long-term PM2.5-exposed mice by suppression of inflammation and oxidative stress. Redox Biol 19:147-157 (2018). PubMed: 30165303
  • Yamamoto K  et al. Inhibition of Shedding of Low-Density Lipoprotein Receptor-Related Protein 1 Reverses Cartilage Matrix Degradation in Osteoarthritis. Arthritis Rheumatol 69:1246-1256 (2017). PubMed: 28235248
  • Barberà-Cremades M  et al. P2X7 Receptor Induces Tumor Necrosis Factor-a Converting Enzyme Activation and Release to Boost TNF-a Production. Front Immunol 8:862 (2017). PubMed: 28791020
  • Zhang M  et al. Transmembrane TNF-a promotes activation-induced cell death by forward and reverse signaling. Oncotarget 8:63799-63812 (2017). PubMed: 28969030
  • Bohrer LR  et al. ADAM17 in tumor associated leukocytes regulates inflammatory mediators and promotes mammary tumor formation. Genes Cancer 7:240-253 (2016). PubMed: 27738494
  • Cai Z  et al. Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration. Cell Res N/A:N/A (2016). PubMed: 27444869
  • Corbett GT  et al. Activation of peroxisome proliferator-activated receptor a stimulates ADAM10-mediated proteolysis of APP. Proc Natl Acad Sci U S A 112:8445-50 (2015). WB ; Mouse . PubMed: 26080426
  • Zhang PP  et al. Astragalus polysaccharide promotes the release of mature granulocytes through the L-selectin signaling pathway. Chin Med 10:17 (2015). PubMed: 26161135
  • Shitomi Y  et al. ADAM10 controls collagen signaling and cell migration on collagen by shedding the ectodomain of discoidin domain receptor 1 (DDR1). Mol Biol Cell 26:659-73 (2015). PubMed: 25540428
  • de Queiroz TM  et al. a-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17. Am J Physiol Heart Circ Physiol 309:H926-34 (2015). PubMed: 26254330
  • Dombernowsky SL  et al. The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17. Nat Commun 6:7518 (2015). IP . PubMed: 26108729
  • Gao F  et al. 4-Hydroxyisoleucine improves insulin resistance in HepG2 cells by decreasing TNF-a and regulating the expression of insulin signal transduction proteins. Mol Med Rep 12:6555-60 (2015). WB . PubMed: 26352439
  • Brooke MA  et al. iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function. Hum Mol Genet N/A:N/A (2014). Human . PubMed: 24643277
  • Parker KH  et al. HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells. Cancer Res 74:5723-33 (2014). PubMed: 25164013
  • Pelullo M  et al. Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALL. Neoplasia 16:1007-17 (2014). PubMed: 25499214
  • Fiaturi N  et al. Dissociated presenilin-1 and TACE processing of ErbB4 in lung alveolar type II cell differentiation. Biochim Biophys Acta 1843:797-805 (2014). PubMed: 24462774
  • Guo LY  et al. Iron increases APP translation and amyloid-beta production in the retina. Exp Eye Res 129:31-7 (2014). WB ; Human . PubMed: 25456519
  • Woods NK & Padmanabhan J Inhibition of amyloid precursor protein processing enhances gemcitabine-mediated cytotoxicity in pancreatic cancer cells. J Biol Chem 288:30114-24 (2013). WB ; Human . PubMed: 24022491
  • Folgosa L  et al. Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-a shedding. J Immunol 191:5951-8 (2013). Mouse . PubMed: 24227779
  • Xia H  et al. Brain angiotensin-converting enzyme type 2 shedding contributes to the development of neurogenic hypertension. Circ Res 113:1087-1096 (2013). PubMed: 24014829
  • Deng Y  et al. Shedding of syndecan-1 from human hepatocytes alters very low density lipoprotein clearance. Hepatology 55:277-86 (2012). WB ; Human . PubMed: 21898481
  • Chanthaphavong RS  et al. A Role for cGMP in Inducible Nitric-oxide Synthase (iNOS)-induced Tumor Necrosis Factor (TNF) a-converting Enzyme (TACE/ADAM17) Activation, Translocation, and TNF Receptor 1 (TNFR1) Shedding in Hepatocytes. J Biol Chem 287:35887-98 (2012). PubMed: 22898814
  • Thorp E  et al. Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase C{delta}, and p38 Mitogen-activated Protein Kinase (MAPK). J Biol Chem 286:33335-44 (2011). PubMed: 21828049
  • Spin JM  et al. Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm. Physiol Genomics 43:993-1003 (2011). IHC . PubMed: 21712436
  • Shirakabe K  et al. VIP36 Protein Is a Target of Ectodomain Shedding and Regulates Phagocytosis in Macrophage Raw 264.7 Cells. J Biol Chem 286:43154-63 (2011). WB ; Mouse . PubMed: 22016386
  • Leksa V  et al. Soluble M6P/IGF2R released by TACE controls angiogenesis via blocking plasminogen activation. Circ Res 108:676-85 (2011). PubMed: 21273553
  • Rabquer BJ  et al. Junctional adhesion molecule-C is a soluble mediator of angiogenesis. J Immunol 185:1777-85 (2010). WB ; Human . PubMed: 20592283
  • Lu Y  et al. Gallic acid suppresses cell viability, proliferation, invasion and angiogenesis in human glioma cells. Eur J Pharmacol 641:102-7 (2010). WB ; Human . PubMed: 20553913
  • Gijsen M  et al. HER2 phosphorylation is maintained by a PKB negative feedback loop in response to anti-HER2 herceptin in breast cancer. PLoS Biol 8:e1000563 (2010). WB ; Human . PubMed: 21203579
  • Hanson EM  et al. Myeloid-derived suppressor cells down-regulate L-selectin expression on CD4+ and CD8+ T cells. J Immunol 183:937-44 (2009). Flow Cyt . PubMed: 19553533
  • Katakowski M  et al. Tumorigenicity of cortical astrocyte cell line induced by the protease ADAM17. Cancer Sci 100:1597-604 (2009). WB ; Mouse . PubMed: 19515085
  • Zheng X  et al. Inhibition of ADAM17 reduces hypoxia-induced brain tumor cell invasiveness. Cancer Sci 98:674-84 (2007). PubMed: 17355261
  • Hakulinen J & Keski-Oja J ADAM10-mediated release of complement membrane cofactor protein during apoptosis of epithelial cells. J Biol Chem 281:21369-76 (2006). PubMed: 16735514
  • Plumb J  et al. ADAM-17 and TIMP3 protein and mRNA expression in spinal cord white matter of rats with acute experimental autoimmune encephalomyelitis. J Neuroimmunol 164:1-9 (2005). PubMed: 15878627


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