Overview

  • Product name

  • Description

    Rabbit polyclonal to ADAM22
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Frmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Positive control

    • WB: IMR32 whole cell lysate. IHC-Fr: Embryonic mouse brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab227546 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 100 kDa.
IHC-Fr 1/100 - 1/1000.

Target

  • Function

    Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1.
  • Tissue specificity

    Highly expressed in the brain and in some high-grade but not low-grade gliomas. Detected slightly or not at all in other tissues.
  • Sequence similarities

    Contains 1 disintegrin domain.
    Contains 1 EGF-like domain.
    Contains 1 peptidase M12B domain.
  • Post-translational
    modifications

    The precursor is cleaved by a furin endopeptidase.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • A disintegrin and metalloproteinase domain 22 antibody
    • ADA22_HUMAN antibody
    • ADAM 22 antibody
    • ADAM metallopeptidase domain 22 antibody
    • adam22 antibody
    • and cysteine-rich protein 2 antibody
    • Disintegrin and metalloproteinase domain-containing protein 22 antibody
    • disintegrin-like antibody
    • MDC 2 antibody
    • MDC2 antibody
    • Metalloproteinase disintegrin ADAM22 3 antibody
    • Metalloproteinase like disintegrin like and cysteine rich protein 2 antibody
    • Metalloproteinase-disintegrin ADAM22-3 antibody
    • Metalloproteinase-like antibody
    • MGC149832 antibody
    see all

Images

  • Anti-ADAM22 antibody (ab227546) at 1/500 dilution + IMR32 (human brain neuroblast cell line) whole cell lysate at 30 µg

    Developed using the ECL technique.

    Predicted band size: 100 kDa



    7.5% SDS-PAGE

  • Frozen sectioned embryonic mouse brain (mE18.5) stained for ADAM22 with ab227546 (1/500 dilution) (red) in immunohistochemical analysis. Counterstains: DAPI (blue).

References

ab227546 has not yet been referenced specifically in any publications.

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