Overview

  • Product name

  • Description

    Rabbit polyclonal to ADAMTS1
  • Host species

    Rabbit
  • Specificity

    Contains 3 TSP type-1 domains.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat, Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide within Mouse ADAMTS1 aa 920-967 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Sequence:

    P CSKTCGKGYK KRTLKCVSHD GGVLSNESCD PLKKPKHYID FCTLTQC


    Database link: P97857

  • Positive control

    • Human lung carcinoma tissue; Rat tongue tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab216977 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

When using a fluorescent probe the recommended dilution is 1/50 – 1/200.

Target

  • Function

    Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture.
  • Sequence similarities

    Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 3 TSP type-1 domains.
  • Domain

    The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications

    The precursor is cleaved by a furin endopeptidase.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • A disintegrin and metalloproteinase with thrombospondin motifs 1 antibody
    • ADAM-TS 1 antibody
    • ADAM-TS1 antibody
    • ADAMTS 1 antibody
    • ADAMTS antibody
    • ADAMTS-1 antibody
    • Adamts1 antibody
    • ATS1_HUMAN antibody
    • C3 C5 antibody
    • KIAA1346, antibody
    • METH 1 antibody
    • METH-1 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed and paraffin-embedded Rat tongue tissue labeling ADAMTS1 with ab216977 at 1/200 dilution, followed by Goat Anti-rabbit IgG, Cy3 conjugated secondary antibody at 1/200 dilution.

  • Immunohistochemical analysis analysis of formalin-fixed and paraffin-embedded Human colon carcinoma tissue labeling ADAMTS1 with ab216977 at 1/200 dilution. Followed by Goat Anti-rabbit IgG, Cy3 conjugated secondary antibody at 1/200 dilution.

  • Immunohistochemical analysis of Formalin-fixed, paraffin-embedded Human lung carcinoma tissue labeling ADAMTS1 with ab216977 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

References

ab216977 has not yet been referenced specifically in any publications.

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