• Product name

    Anti-ADAMTS13 antibody [EPR6132]
    See all ADAMTS13 primary antibodies
  • Description

    Rabbit monoclonal [EPR6132] to ADAMTS13
  • Host species

  • Tested applications

    Suitable for: WB, Flow Cytmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human ADAMTS13 aa 50-150 (Cysteine residue). The exact sequence is proprietary.
    Database link: Q76LX8

  • Positive control

    • Human fetal liver, A549 and HepG2 whole cell lysate (ab7900); A549 cells.
  • General notes



    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result of this work we are pleased to now offer this antibody in purified format. We are in the process of updating our datasheets. The purified format is designated 'PUR' on our product labels. If you have any questions regarding this update, please contact our Scientific Support team.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab177940 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Detects a band of approximately 190 kDa (predicted molecular weight: 154 kDa).
Flow Cyt 1/100 - 1/500.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.


  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Function

      Cleaves the vWF multimers in plasma into smaller forms.
    • Tissue specificity

      Plasma. Expressed primarily in liver.
    • Involvement in disease

      Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP) [MIM:274150]; also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever.
    • Sequence similarities

      Contains 2 CUB domains.
      Contains 1 disintegrin domain.
      Contains 1 peptidase M12B domain.
      Contains 8 TSP type-1 domains.
    • Domain

      The pro-domain is not required for folding or secretion and does not perform the common function of maintening enzyme latency.
      The spacer domain is necessary to recognize and cleave vWF. The C-terminal TSP type-1 and CUB domains may modulate this interaction.
    • Post-translational

      May contain a C-mannosylation site and O-fucosylation sites in the TSP type-1 domains.
      The precursor is processed by a furin endopeptidase which cleaves off the pro-domain.
    • Cellular localization

    • Information by UniProt
    • Database links

    • Alternative names

      • A disintegrin and metalloproteinase with thrombospondin motifs 13 antibody
      • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 13 antibody
      • A disintegrin like and metalloprotease with thrombospondin type 1 motif 13 antibody
      • ADAM metallopeptidase with thrombospondin type 1 motif 13 antibody
      • ADAM TS antibody
      • ADAM-TS 13 antibody
      • ADAM-TS13 antibody
      • ADAMTS 13 antibody
      • ADAMTS-13 antibody
      • ADAMTS13 antibody
      • ADAMTS13 protein antibody
      • ATS13_HUMAN antibody
      • C9orf8 antibody
      • TTP antibody
      • Von Willebrand factor cleaving protease antibody
      • von Willebrand factor-cleaving protease antibody
      • vWF cleaving protease antibody
      • vWF CP antibody
      • vWF-cleaving protease antibody
      • vWF-CP antibody
      • vWFCP antibody
      see all


    • All lanes : Anti-ADAMTS13 antibody [EPR6132] (ab177940) at 1/1000 dilution

      Lane 1 : Human fetal liver lysate
      Lane 2 : A549 cell lysate
      Lane 3 : HepG2 lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 154 kDa

    • Flow cytometric analysis of permeabilized A549 cells labeling ADAMTS13 with ab177940 at 1/100 dilution.


    This product has been referenced in:

    • Liu-Chen S  et al. mRNA treatment produces sustained expression of enzymatically active human ADAMTS13 in mice. Sci Rep 8:7859 (2018). Read more (PubMed: 29777164) »
    See 1 Publication for this product

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