Anti-ADAMTS14 antibody (ab198885)
Key features and details
- Rabbit polyclonal to ADAMTS14
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-ADAMTS14 antibody -
Description
Rabbit polyclonal to ADAMTS14 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human ADAMTS14 (internal sequence). NP_542453.
Database link: Q8WXS8 -
Positive control
- Human breast cancer tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab198885 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/25 - 1/100.
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Notes |
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IHC-P
1/25 - 1/100. |
Target
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Relevance
ADAMTS14 is a member of the ADAMs family of proteinases with 4 thrombospondin (TS)-like domains. These TS motifs are thought to bind ADAMTS14 to the ECM. ADAMTS14 is closest in homology to ADAMTS3, sharing 63% overall identity. ADAMTS14 has a PLAC (Protease and LACunin) domain at the carboxyterminal end, containing a 6 cysteine conserved repeat. The sequence also contains a prohormone-convertase cleavage site (predicted PC cleavage site is the RKRR252 sequence). Several splice variants of ADAMTS-14 have been reported. ADAMTS14 has been shown to be a potential factor in multiple sclerosis (MS), by linkage analysis. ADAMTS14 is expressed in many tissues including lung, brain, liver and placenta. -
Cellular localization
Secreted -
Database links
- Entrez Gene: 140766 Human
- Omim: 607506 Human
- SwissProt: Q8WXS8 Human
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Alternative names
- A disintegrin and metalloproteinase with thrombospondin motifs 14 antibody
- ADAM TS14 antibody
- ADAMTS 14 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (3)
ab198885 has been referenced in 3 publications.
- Chen Y et al. Survival Prognosis, Tumor Immune Landscape, and Immune Responses of ADAMTS14 in Clear Cell Renal Cell Carcinoma and Its Potential Mechanisms. Front Immunol 13:790608 (2022). PubMed: 35572505
- Yang L et al. Comprehensive comparative analysis of histopathology and gene expression in subchondral bone between kashin-beck disease and primary osteoarthritis. Front Genet 13:942326 (2022). PubMed: 35923709
- Lin YM et al. Decreased Cytoplasmic Expression of ADAMTS14 Is Correlated with Reduced Survival Rates in Oral Squamous Cell Carcinoma Patients. Diagnostics (Basel) 10:N/A (2020). PubMed: 32102222