Overview

  • Product name

    Anti-ADAMTS17 antibody
  • Description

    Rabbit polyclonal to ADAMTS17
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide corresponding to Human ADAMTS17 (internal sequence). NP_620688.
    Database link: Q8TE56

  • Positive control

    • NIH 3T3 cell lysate; Human thyroid cancer tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab198881 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.
WB 1/500 - 1/2000. Predicted molecular weight: 121 kDa.

Target

  • Tissue specificity

    Isoform 1 and isoform 2 are expressed at high levels in the lung, brain, whole eye and retina. Isoform 1 shows a weaker expression in the heart, kidney and skeletal muscle. Isoform 2 shows a weaker expression in the kidney, bone marrow and skeletal muscle. Isoform 1 and isoform 2 are expressed at high levels in the fetal heart, kidney, and whole eye, whereas a weak expression is seen in the fetal liver.
  • Involvement in disease

    Defects in ADAMTS17 are the cause of Weill-Marchesani-like syndrome (WMLS) [MIM:613195]. It is a disorder characterized by many of the key features of Weill-Marchesani syndrome, including lenticular myopia, ectopia lentis, glaucoma, spherophakia and short stature. However, the characteristic brachydactyly or decreased joint flexibility of Weill-Marchesani syndrome are absent.
  • Sequence similarities

    Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 1 PLAC domain.
    Contains 5 TSP type-1 domains.
  • Domain

    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • Post-translational
    modifications

    The precursor is cleaved by a furin endopeptidase.
  • Cellular localization

    Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • A disintegrin and metalloproteinase with thrombospondin motifs 17 antibody
    • A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 17 antibody
    • ADAM metallopeptidase with thrombospondin type 1 motif, 17 antibody
    • ADAM-TS 17 antibody
    • ADAM-TS17 antibody
    • ADAMTS 17 antibody
    • ADAMTS-17 antibody
    • ADAMTS17 antibody
    • ATS17_HUMAN antibody
    • EC 3.4.24. antibody
    • FLJ16363 antibody
    • FLJ32769 antibody
    • OTTHUMP00000194818 antibody
    see all

Images

  • Anti-ADAMTS17 antibody (ab198881) at 1/1300 dilution + NIH 3T3 cell lysate at 40 µg

    Developed using the ECL technique.

    Predicted band size: 121 kDa


    Exposure time: 1 hour


    Gel: 8% SDS-PAGE

  • Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling ADAMTS17 with ab198881 at 1/60 dilution.

References

ab198881 has not yet been referenced specifically in any publications.

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