Anti-ADAMTS5 antibody (ab41037)

Rabbit polyclonal ADAMTS5 antibody. Validated in WB, IHC and tested in Mouse, Rat, Human. Cited in 36 publication(s). Independently reviewed in 6 review(s).

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ab41037 has been referenced in 36 publications.

  • Takahata Y  et al. Sox4 is involved in osteoarthritic cartilage deterioration through induction of ADAMTS4 and ADAMTS5. FASEB J 33:619-630 (2019). PubMed: 30016600
  • Li X  et al. LncRNA PMS2L2 protects ATDC5 chondrocytes against lipopolysaccharide-induced inflammatory injury by sponging miR-203. Life Sci 217:283-292 (2019). PubMed: 30550887
  • Li L  et al. CPEB1 Expression Correlates with Severity of Posttraumatic Ankle Osteoarthritis and Aggravates Catabolic Effect of IL-1ß on Chondrocytes. Inflammation N/A:N/A (2018). PubMed: 30411210
  • Ji ML  et al. Preclinical development of a microRNA-based therapy for intervertebral disc degeneration. Nat Commun 9:5051 (2018). PubMed: 30487517
  • Liang S  et al. Necrostatin-1 Attenuates Trauma-Induced Mouse Osteoarthritis and IL-1ß Induced Apoptosis via HMGB1/TLR4/SDF-1 in Primary Mouse Chondrocytes. Front Pharmacol 9:1378 (2018). PubMed: 30542285
  • Zhang G  et al. Detection of miR-29a in plasma of patients with lumbar spinal stenosis and the clinical significance. Mol Med Rep 18:223-229 (2018). PubMed: 29749498
  • Lin H  et al. Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFß-dependent manner and limits osteoarthritis in mice. Sci Rep 8:10488 (2018). PubMed: 29992982
  • Chen Y  et al. Berberine suppresses apoptosis and extracellular matrix (ECM) degradation in nucleus pulposus cells and ameliorates disc degeneration in a rodent model. Int J Biol Sci 14:682-692 (2018). PubMed: 29904282
  • Hui T  et al. Activation of ß-catenin signaling in aggrecan-expressing cells in temporomandibular joint causes osteoarthritis-like defects. Int J Oral Sci 10:13 (2018). IHC-P ; Mouse . PubMed: 29686224
  • Sun W  et al. miR-4262 regulates chondrocyte viability, apoptosis, autophagy by targeting SIRT1 and activating PI3K/AKT/mTOR signaling pathway in rats with osteoarthritis. Exp Ther Med 15:1119-1128 (2018). PubMed: 29434702
  • Wang G  et al. Lycorine Suppresses Endplate-Chondrocyte Degeneration and Prevents Intervertebral Disc Degeneration by Inhibiting NF-?B Signalling Pathway. Cell Physiol Biochem 45:1252-1269 (2018). PubMed: 29448253
  • Chen L  et al. MiR-29b-3p promotes chondrocyte apoptosis and facilitates the occurrence and development of osteoarthritis by targeting PGRN. J Cell Mol Med 21:3347-3359 (2017). WB . PubMed: 28609022
  • Li F  et al. ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol 37:1339-1351 (2017). PubMed: 28546218
  • Nomura M  et al. Thinning of articular cartilage after joint unloading or immobilization. An experimental investigation of the pathogenesis in mice. Osteoarthritis Cartilage 25:727-736 (2017). PubMed: 27916560
  • Xu T  et al. Hedgehog signal expression in articular cartilage of rat temporomandibular joint and association with adjuvant-induced osteoarthritis. J Oral Pathol Med 46:284-291 (2017). PubMed: 27646982
  • Qin Y  et al. Augmented expression of cardiac ankyrin repeat protein is induced by pemetrexed and a possible marker for the pemetrexed resistance in mesothelioma cells. Cancer Cell Int 17:120 (2017). PubMed: 29238267
  • Wang Y  et al. Exosomes from embryonic mesenchymal stem cells alleviate osteoarthritis through balancing synthesis and degradation of cartilage extracellular matrix. Stem Cell Res Ther 8:189 (2017). PubMed: 28807034
  • Ding L  et al. DAMPs Synergize with Cytokines or Fibronectin Fragment on Inducing Chondrolysis but Lose Effect When Acting Alone. Mediators Inflamm 2017:2642549 (2017). WB . PubMed: 28804219
  • Liu YD  et al. Systemic administration of strontium or NBD peptide ameliorates early stage cartilage degradation of mouse mandibular condyles. Osteoarthritis Cartilage 24:178-187 (2016). PubMed: 26256766
  • Rockel JS  et al. Hedgehog inhibits ß-catenin activity in synovial joint development and osteoarthritis. J Clin Invest 126:1649-63 (2016). PubMed: 27018594
  • Yang W  et al. Clock gene Bmal1 modulates human cartilage gene expression by crosstalk with Sirt1. Endocrinology N/A:en20152042 (2016). WB ; Human . PubMed: 27253997
  • Lu W  et al. CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci 17:N/A (2016). Rat . PubMed: 27690009
  • Lemarchant S  et al. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. Mol Neurodegener 11:10 (2016). WB ; Mouse . PubMed: 26809777
  • Camacho A  et al. Iron overload in a murine model of hereditary hemochromatosis is associated with accelerated progression of osteoarthritis under mechanical stress. Osteoarthritis Cartilage 24:494-502 (2016). PubMed: 26403062
  • Zhu S  et al. Down-regulation of Rac GTPase-activating protein OCRL1 causes aberrant activation of Rac1 in osteoarthritis development. Arthritis Rheumatol 67:2154-63 (2015). PubMed: 25917196
  • Xia Q  et al. Intra-articular transplantation of atsttrin-transduced mesenchymal stem cells ameliorate osteoarthritis development. Stem Cells Transl Med 4:523-31 (2015). IHC, ICC/IF ; Human . PubMed: 25824140
  • Filou S  et al. ADAMTS expression in colorectal cancer. PLoS One 10:e0121209 (2015). PubMed: 25786261
  • Li C  et al. Lost expression of ADAMTS5 protein associates with progression and poor prognosis of hepatocellular carcinoma. Drug Des Devel Ther 9:1773-83 (2015). IHC, WB ; Human . PubMed: 25848214
  • Zhu S  et al. Programmed Application of Transforming Growth Factor ß3 and Rac1 Inhibitor NSC23766 Committed Hyaline Cartilage Differentiation of Adipose-Derived Stem Cells for Osteochondral Defect Repair. Stem Cells Transl Med 3:1242-51 (2014). PubMed: 25154784
  • Zhang X  et al. Reduced EGFR signaling enhances cartilage destruction in a mouse osteoarthritis model. Bone Res 2:14015 (2014). PubMed: 26120493
  • Lai A  et al. Structural, compositional, and biomechanical alterations of the lumbar spine in rats with mucopolysaccharidosis type VI (Maroteaux-Lamy syndrome). J Orthop Res 31:621-31 (2013). PubMed: 23192728
  • Zhu S  et al. Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo. Ann Rheum Dis N/A:N/A (2013). IHC-P, ICC/IF ; Human . PubMed: 24257023
  • Funck-Brentano T  et al. Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism. PLoS One 7:e33543 (2012). IHC-P ; Mouse . PubMed: 22432033
  • Krstic D  et al. Regulated proteolytic processing of Reelin through interplay of tissue plasminogen activator (tPA), ADAMTS-4, ADAMTS-5, and their modulators. PLoS One 7:e47793 (2012). PubMed: 23082219
  • Wang J  et al. TNF-a and IL-1ß Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc. J Biol Chem 286:39738-49 (2011). WB ; Human, Rat . PubMed: 21949132
  • Keller KE  et al. Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork. Invest Ophthalmol Vis Sci 50:5769-77 (2009). PubMed: 19553617

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