• Product name
  • Description
    Rabbit polyclonal to ADAMTS7
  • Host species
  • Specificity
    ab28557 recognizes metalloproteinase ADAMTS7.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human ADAMTS7. Immunogen in the spacer-1 region of the C-terminus.



Our Abpromise guarantee covers the use of ab28557 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    WB: 1/1,000 when using colorimetric substrates such as BCIP/NBT and 1/5,000 for chemiluminescent substrates. Predicted molecular weight: 184 kDa. This antibody recognizes the zymogen of ADAMTS7 at around 300 kD in reduced Western blots, activated or alternatively spliced forms at 180-120 kD (major bands) and breakdown products at 58-45 kD in cell lysates. EDTA/EGTA treatment of tissues or lysates is required to see latent zymogen. Dilution optimised using Chromogenic detection. Not yet tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Metalloprotease that may play a role in the degradation of COMP.
    • Tissue specificity
      Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Detected in meniscus, bone, tendon, cartilage, synovium, fat and ligaments.
    • Sequence similarities
      Contains 1 disintegrin domain.
      Contains 1 peptidase M12B domain.
      Contains 1 PLAC domain.
      Contains 8 TSP type-1 domains.
    • Domain
      The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
      The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
    • Post-translational
      N-glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan. Contains chondroitin sulfate.
      May be cleaved by a furin endopeptidase (By similarity). The precursor is sequentially processed.
    • Cellular localization
      Secreted, extracellular space, extracellular matrix. Also found associated with the external cell surface.
    • Information by UniProt
    • Database links
    • Alternative names
      • A disintegrin and metalloprotease with thrombospondin motifs 7 preproprotein antibody
      • A disintegrin and metalloproteinase with thrombospondin motifs 7 antibody
      • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 7 antibody
      • A disintegrin like and metalloprotease with thrombospondin type 1 motif 7 antibody
      • ADAM metallopeptidase with thrombospondin type 1 motif 7 antibody
      • ADAM metallopeptidase with thrombospondin type 1 motif 7 preproprotein antibody
      • ADAM TS 7 antibody
      • ADAM TS7 antibody
      • ADAM-TS 7 antibody
      • ADAM-TS7 antibody
      • ADAMTS 7 antibody
      • ADAMTS-7 antibody
      • Adamts7 antibody
      • ATS7_HUMAN antibody
      • COMPase antibody
      • DKFZp434H204 antibody
      see all


    This product has been referenced in:
    • Chan K  et al. Genetic Variation at theADAMTS7Locus is Associated With Reduced Severity of Coronary Artery Disease. J Am Heart Assoc 6:N/A (2017). IHC-P ; Human . Read more (PubMed: 29089340) »
    • Pu X  et al. ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. Am J Hum Genet 92:366-74 (2013). Read more (PubMed: 23415669) »

    See all 2 Publications for this product

    Customer reviews and Q&As

    Thank you for your feedback. I am sorry to hear you have experienced problems with ab28557. The quality of our products is extremely important to us, so thank you for bringing this to our attention. I can confirm that the immunogen is a ...

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