• Product name
  • Description
    Rabbit polyclonal to ADCK3
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to internal sequence amino acids 395-423 of Human CABC1 (NP_075830.1, NP_001156762.1).

  • Positive control
    • Mouse bladder tissue.



Our Abpromise guarantee covers the use of ab124237 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 72 kDa.


  • Function
    May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain.
  • Tissue specificity
    Ubiquitously expressed with a relatively greater abundance in heart and skeletal muscle.
  • Involvement in disease
    Defects in ADCK3 are a cause of coenzyme Q10 deficiency (CoQ10 deficiency) [MIM:607426]. CoQ10 deficiency is an autosomal recessive disorder with variable manifestations. It can be associated with three main clinical phenotypes: a predominantly myopathic form with central nervous system involvement, an infantile encephalomyopathy with renal dysfunction and an ataxic form with cerebellar atrophy.
    Defects in ADCK3 are the cause of spinocerebellar ataxia autosomal recessive type 9 (SCAR9) [MIM:612016]; also known as autosomal recessive cerebellar ataxia type 2 (ARCA2). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR9 is an autosomal recessive form characterized by gait ataxia and cerebellar atrophy with slow progression and few associated features. Patients can manifest brisk tendon reflexes and Hoffmann sign, mild psychomotor retardation, mild axonal degeneration of the sural nerve, exercise intolerance and elevated serum lactate.
  • Sequence similarities
    Belongs to the protein kinase superfamily. ADCK protein kinase family.
    Contains 1 protein kinase domain.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • aarF domain containing protein kinase 3 antibody
    • aarF domain-containing protein kinase 3 antibody
    • ADCK 3 antibody
    • Adck3 antibody
    • ADCK3_HUMAN antibody
    • ARCA2 antibody
    • CABC 1 antibody
    • CABC1 antibody
    • Chaperone ABC1 (activity of bc1 complex S.pombe) like antibody
    • Chaperone ABC1 activity of bc1 complex homolog antibody
    • Chaperone ABC1 like antibody
    • Chaperone activity of bc1 complex like antibody
    • Chaperone activity of bc1 complex like mitochondrial antibody
    • Chaperone activity of bc1 complex-like antibody
    • Chaperone-ABC1-like antibody
    • Coenzyme Q8 homolog antibody
    • COQ 8 antibody
    • COQ10D4 antibody
    • COQ8 antibody
    • COQ8, S. cerevisiae, homolog of antibody
    • MGC4849 antibody
    • mitochondrial antibody
    • OTTHUMP00000035734 antibody
    • OTTHUMP00000035737 antibody
    • SCAR9 antibody
    see all


  • Anti-ADCK3 antibody (ab124237) at 1/100 dilution + mouse bladder tissue lysates at 35 µg

    Predicted band size: 72 kDa


This product has been referenced in:
  • Rooney MF  et al. Skeletal muscle mitochondrial bioenergetics and associations with myostatin genotypes in the Thoroughbred horse. PLoS One 12:e0186247 (2017). Read more (PubMed: 29190290) »

See 1 Publication for this product

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