Adefovir Dipivoxil (bis-POM PMEA), nucleotide analog reverse transcriptase inhibitor (ab143063)

Overview

  • Product name

    Adefovir Dipivoxil (bis-POM PMEA), nucleotide analog reverse transcriptase inhibitor
  • Description

    Potent, selective, nucleotide analog reverse transcriptase inhibitor
  • Alternative names

    • bis-POM PMEA
  • Biological description

    Potent, selective, nucleotide analog reverse transcriptase inhibitor. Inhibits viral DNA synthesis (IC50 = 0.2-2.5 μM, HBV transfected human hepatoma cell lines). Shows antiviral effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    142340-99-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Li P  et al. Reversible inhibitory effects of saturated and unsaturated alkyl esters on the carboxylesterases activity in rat intestine. Lipids 45:603-12 (2010). Read more (PubMed: 20532832) »
  • Zídek Z  et al. In vivo effects of antiviral acyclic nucleoside phosphonate 9-[2-(phosphonomethoxy)ethyl]adenine (adefovir) on cytochrome P450 system of rat liver microsomes. J Biomed Sci 13:295-301 (2006). Read more (PubMed: 16416053) »
  • Hatse S  et al. Potent antitumor activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl)adenine in choriocarcinoma-bearing rats. Int J Cancer 76:595-600 (1998). Read more (PubMed: 9590139) »

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