Adefovir, Nucleotide analog reverse transcriptase inhibitor (ab143568)

Overview

  • Product name

    Adefovir, Nucleotide analog reverse transcriptase inhibitor
  • Description

    Nucleotide analog reverse transcriptase inhibitor. Antiviral agent.
  • Biological description

    Nucleotide analog reverse transcriptase inhibitor (Ki = 100 nM, HBV DNA polymerase). Antiviral agent. cAMP analog. MRP4 substrate. Shows antireplication effects against hepatitis B in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    106941-25-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Park J  et al. Na?/H? exchanger regulatory factor 3 is critical for multidrug resistance protein 4-mediated drug efflux in the kidney. J Am Soc Nephrol 25:726-36 (2014). Read more (PubMed: 24436471) »
  • Menéndez-Arias L  et al. Nucleoside/nucleotide analog inhibitors of hepatitis B virus polymerase: mechanism of action and resistance. Curr Opin Virol 8C:1-9 (2014). Read more (PubMed: 24814823) »
  • Fukuda Y  et al. Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity. Mol Pharmacol 84:361-71 (2013). Read more (PubMed: 23775562) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab143568.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up