Anti-Adenine Nucleotide Translocase 1 / ANT 1 antibody (ab180715)

Overview

  • Product name
    Anti-Adenine Nucleotide Translocase 1 / ANT 1 antibody
    See all Adenine Nucleotide Translocase 1 / ANT 1 primary antibodies
  • Description
    Rabbit polyclonal to Adenine Nucleotide Translocase 1 / ANT 1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant fragment corresponding to Human Adenine Nucleotide Translocase 1/ ANT 1 aa 40-298.
    Sequence:

    H ASKQISAEKQ YKGIIDCVVR IPKEQGFLSF WRGNLANVIR YFPTQALNFA FKDKYKQLFL GGVDRHKQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKGAA QREFHGLGDC IIKIFKSDGL RGLYQGFNVS VQGIIIYRAA YFGVYDTAKG MLPDPKNVHI FVSWMIAQSV TAVAGLVSYP FDTVRRRMMM QSGRKGADIM YTGTVDCWRK IAKDEGAKAF FKGAWSNVLR GMGGAFVLVL YDEIKKYV


    Database link: P12235

  • Positive control
    • SW620, BT474, OVCAR3, HepG2 and Mouse brain extracts
  • General notes

    Previously labelled as Adenine Nucleotide Translocase 1. 

Properties

Applications

Our Abpromise guarantee covers the use of ab180715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

WB 1/500 - 1/2000. Predicted molecular weight: 33 kDa.

Target

  • Function
    Catalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.
  • Involvement in disease
    Defects in SLC25A4 are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 2 (PEOA2) [MIM:609283]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
  • Sequence similarities
    Belongs to the mitochondrial carrier family.
    Contains 3 Solcar repeats.
  • Cellular localization
    Mitochondrion inner membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AAC1 antibody
    • Adenine Nucleotide Translocase 1 antibody
    • Adenine nucleotide translocator 1 (skeletal muscle) antibody
    • Adenine nucleotide translocator 1 antibody
    • ADP antibody
    • ADP ATP carrier protein 1 antibody
    • ADP ATP carrier protein heart/skeletal muscle isoform T1 antibody
    • ADP/ATP translocase 1 antibody
    • ADT1_HUMAN antibody
    • ANT 1 antibody
    • ANT antibody
    • ANT1 antibody
    • ATP carrier protein 1 antibody
    • ATP carrier protein antibody
    • heart/skeletal muscle isoform T1 antibody
    • PEO2 antibody
    • PEO3 antibody
    • SLC25A4 antibody
    • Solute carrier family 25 member 4 antibody
    • T1 antibody
    see all

Images

  • All lanes : Anti-Adenine Nucleotide Translocase 1 / ANT 1 antibody (ab180715) at 1/500 dilution

    Lane 1 : SW620 cell extracts
    Lane 2 : BT474 cell extracts
    Lane 3 : OVCAR3 cell extracts
    Lane 4 : HepG2 cell extracts
    Lane 5 : Mouse brain cell extracts

    Predicted band size: 33 kDa

References

This product has been referenced in:
  • Laker RC  et al. The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis. PLoS One 11:e0167910 (2016). WB . Read more (PubMed: 28005946) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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