Key features and details
- Rabbit polyclonal to Adenine Nucleotide Translocase 1/ANT 1
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Adenine Nucleotide Translocase 1/ANT 1 antibody
See all Adenine Nucleotide Translocase 1/ANT 1 primary antibodies
DescriptionRabbit polyclonal to Adenine Nucleotide Translocase 1/ANT 1
This antibody is named based on homology. It can also recognise ADP/ATP translocase 2, SLC25A31, SLC25A5 and SLC25A6 due to homology of 93% in immunogen sequence.
Tested applicationsSuitable for: IHC-P, WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Cow
- IHC-P: Human cerebellum, kidney and duodenum tissue. WB: RT-4 and U-251 MG cell lysate.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 40% Glycerol (glycerin, glycerine), PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab221956 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/20 - 1/50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
|WB||Use a concentration of 0.04 - 0.4 µg/ml. Predicted molecular weight: 33 kDa.|
FunctionCatalyzes the exchange of ADP and ATP across the mitochondrial inner membrane.
Involvement in diseaseDefects in SLC25A4 are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 2 (PEOA2) [MIM:609283]. Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
Sequence similaritiesBelongs to the mitochondrial carrier family.
Contains 3 Solcar repeats.
Cellular localizationMitochondrion inner membrane.
- Information by UniProt
- AAC1 antibody
- Adenine Nucleotide Translocase 1 antibody
- Adenine nucleotide translocator 1 (skeletal muscle) antibody
Paraffin embedded human cerebellum tissue stained for Adenine Nucleotide Translocase 1/ANT 1 with ab221956 (1/20 dilution) in immunohistochemical analysis.
Paraffin embedded human kidney tissue stained for Adenine Nucleotide Translocase 1/ANT 1 with ab221956 (1/20 dilution) in immunohistochemical analysis.
Paraffin embedded human duodenum tissue stained for Adenine Nucleotide Translocase 1/ANT 1 with ab221956 (1/20 dilution) in immunohistochemical analysis.
All lanes : Anti-Adenine Nucleotide Translocase 1/ANT 1 antibody (ab221956) at 1/100 dilution
Lane 1 : RT-4 cell lysate
Lane 2 : U-251 MG cell lysate
Predicted band size: 33 kDa
ab221956 has not yet been referenced specifically in any publications.