Product nameAdiphenine hydrochloride, Nicotinic acetylcholine receptor (nAChR) inhibitor
DescriptionNon-competitive Nicotinic acetylcholine receptor (nAChR) inhibitor. Used as an antispasmodic drug.
- Adiphenine HCl
- Diphenylacetic acid 2-(diethylamino)ethyl ester
Non-competitive Nicotinic acetylcholine receptor (nAChR) inhibitor. Used as an antispasmodic drug.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 75 mM, in water to 100 mM and in ethanol to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Spitzmaul G et al. The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms. Br J Pharmacol 157:804-17 (2009). Read more (PubMed: 19422391) »
- McKay DB & Trent-Sanchez P Effect of noncompetitive nicotinic receptor blockers on catecholamine release from cultured adrenal chromaffin cells. Pharmacology 40:224-30 (1990). Read more (PubMed: 1697077) »
- TANAKA K Anticonvulsant properties of procaine, cocaine, adiphenine and related structures. Proc Soc Exp Biol Med 90:192-5 (1955). Read more (PubMed: 13273394) »