Overview

  • Product name

  • Description

    Goat polyclonal to ADIPOR1
  • Host species

    Goat
  • Specificity

    Recognizes Human ADPR1 Receptor. Not likely to cross react with ADPR2.
  • Tested applications

    Suitable for: WB, IHC-P, ICCmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Cat, Pig, Xenopus laevis
  • Immunogen

    Synthetic peptide corresponding to Human ADIPOR1 aa 317-340 (C terminal).
    Sequence:

    CYAARIPERFFPGKFDIWFQSHQIF

  • Positive control

    • Human liver tissue and human muscle tissue
  • General notes

     This product was previously labelled as Adiponectin Receptor 1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab77611 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-P
ICC
  • Application notes
    ICC: 1/400 (acetone fixed cells).
    IHC-P: 1/250. Recommended buffer: 10 mM KHPO4, 140 mM NaCl, pH 7.2.
    WB: 1/1000. Predicted molecular weight: 42 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.
    • Tissue specificity

      Widely expressed. Highly expressed in skeletal muscle. Expressed at intermediate level in brain, heart, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes. Weakly expressed in colon, thymus and small intestine.
    • Sequence similarities

      Belongs to the ADIPOR family.
    • Domain

      The N-terminus is known to be cytoplasmic while the C-terminus is known to be extracellular.
    • Cellular localization

      Membrane. Localized to the cell membrane and intracellular organelles.
    • Information by UniProt
    • Database links

    • Alternative names

      • ACDCR1 antibody
      • ADIPO R1 antibody
      • Adiponectin receptor protein 1 antibody
      • ADIPOR 1 antibody
      • Adipor1 antibody
      • ADR1_HUMAN antibody
      • CGI 45 antibody
      • CGI 45 protein antibody
      • CGI-45 antibody
      • CGI45 antibody
      • CGI45 protein antibody
      • FLJ25385 antibody
      • FLJ42464 antibody
      • PAQR1 antibody
      • Progestin and adipoQ receptor family member I antibody
      • TESBP1A antibody
      see all

    Images

    • Paraffin section of human liver tissue stained using antibody to human ADPR1 receptor C-terminus ab77611 at 1/250 dilution.
    • Paraffin section of human muscle tissue stained using antibody to human ADPR1 receptor C-terminus ab77611 at 1/250 dilution.

    References

    This product has been referenced in:

    • Abdalla BA  et al. A Novel Dnmt3a1 Transcript Inhibits Adipogenesis. Front Physiol 9:1270 (2018). Read more (PubMed: 30333755) »
    • Basu S  et al. Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen. PLoS One 10:e0138443 (2015). Read more (PubMed: 26431176) »
    See all 3 Publications for this product

    Customer reviews and Q&As

    1-2 of 2 Abreviews or Q&A

    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Human Tissue sections (Liver)
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: Citric acid
    Permeabilization
    No
    Specification
    Liver
    Blocking step
    Normal goat serum as blocking agent for 15 minute(s) · Concentration: 10% · Temperature: 25°C
    Fixative
    Paraformaldehyde

    Abcam user community

    Verified customer

    Submitted Apr 08 2010

    Application
    Flow Cytometry
    Sample
    Human Cell (mesothelioma)
    Permeabilization
    No
    Gating Strategy
    R2
    Specification
    mesothelioma
    Fixation
    non-fix

    Abcam user community

    Verified customer

    Submitted Jan 27 2010

    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
    For licensing inquiries, please contact partnerships@abcam.com

    Sign up