Overview

  • Product name

    AdipoRon, Adiponectin receptor agonist
  • Description

    Adiponectin receptor agonist
  • Biological description

    Adiponectin receptor agonist (KD values are 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively). AMPK and PPARα signaling activator. Shows antiobesogenic, antidiabetic and cardioprotective effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    924416-43-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide
  • Molecular weight

    428.52
  • Molecular formula

    C27H28N2O3
  • PubChem identifier

    16307093
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Lee S & Kwak HB Role of adiponectin in metabolic and cardiovascular disease. J Exerc Rehabil 10:54-9 (2014). Read more (PubMed: 24877038) »
  • Yang N  et al. Weight loss herbal intervention therapy (W-LHIT) a non-appetite suppressing natural product controls weight and lowers cholesterol and glucose levels in a murine model. BMC Complement Altern Med 14:261 (2014). Read more (PubMed: 25055851) »
  • Okada-Iwabu M  et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature 503:493-9 (2013). Read more (PubMed: 24172895) »

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