AdipoRon, Adiponectin receptor agonist (ab144867)
Key features and details
- Adiponectin receptor agonist
- CAS Number: 924416-43-3
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
AdipoRon, Adiponectin receptor agonist -
Description
Adiponectin receptor agonist -
Biological description
Adiponectin receptor agonist (KD values are 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively). AMPK and PPARα signaling activator. Shows antiobesogenic, antidiabetic and cardioprotective effects in vivo. Orally active.
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Purity
> 98% -
CAS Number
924416-43-3 -
Chemical structure
Properties
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Chemical name
2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide -
Molecular weight
428.52 -
Molecular formula
C27H28N2O3 -
PubChem identifier
16307093 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 100 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4 -
Source
Synthetic
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Research areas
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipoprotein metabolism
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
Images
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Chemical Structure - AdipoRon, Adiponectin receptor agonist (ab144867)2D chemical structure image of ab144867, AdipoRon, Adiponectin receptor agonist
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (1)
ab144867 has been referenced in 1 publication.
- Wang YT et al. Contribution of transcription factor EB to adipoRon-induced inhibition of arterial smooth muscle cell proliferation and migration. Am J Physiol Cell Physiol 317:C1034-C1047 (2019). PubMed: 31483704