Key features and details
- Rabbit polyclonal to ADRA1B
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-ADRA1B antibody
See all ADRA1B primary antibodies
DescriptionRabbit polyclonal to ADRA1B
SpecificityBLAST analysis of the peptide immunogen showed no homology with other Human proteins, except PLEKHG5 (45%).
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Hamster, Cow, Dog, Monkey, Gorilla, Common marmoset, Bat, Elephant
Synthetic peptide corresponding to Human ADRA1B (C terminal).
Database link: NP_000670.1
- Human adrenal (medulla) tissue.
This product was previously labelled as alpha 1b Adrenergic Receptor
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab140692 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 11 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionThis alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1B sub-subfamily.
Cellular localizationNucleus membrane. Cell membrane. Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes.
- Information by UniProt
- ADA1B_HUMAN antibody
- ADRA 1 antibody
- Adra 1b antibody
ab140692 has not yet been referenced specifically in any publications.