Anti-Adrenomedullin/ADM antibody (ab190819)
Key features and details
- Rabbit polyclonal to Adrenomedullin/ADM
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG
Overview
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Product name
Anti-Adrenomedullin/ADM antibody -
Description
Rabbit polyclonal to Adrenomedullin/ADM -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse
Predicted to work with: Rat, Human -
Immunogen
Synthetic peptide within Human Adrenomedullin/ADM aa 100 to the C-terminus (internal sequence). The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
Database link: P35318 -
Positive control
- Mouse kidney extract.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 0.87% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS without Mg2+ and Ca2+. -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
ab190819 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific peptide. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab190819 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (2) |
1/500 - 1/1000. Predicted molecular weight: 20 kDa.
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Notes |
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WB
1/500 - 1/1000. Predicted molecular weight: 20 kDa. |
Target
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Function
AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. -
Tissue specificity
Highest levels found in pheochromocytoma and adrenal medulla. Also found in lung, ventricle and kidney tissues. -
Sequence similarities
Belongs to the adrenomedullin family. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 133 Human
- Entrez Gene: 11535 Mouse
- Entrez Gene: 25026 Rat
- Omim: 103275 Human
- SwissProt: P35318 Human
- SwissProt: P97297 Mouse
- SwissProt: P43145 Rat
- Unigene: 441047 Human
see all -
Alternative names
- Adm antibody
- ADM precursor antibody
- ADML_HUMAN antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab190819 has been referenced in 1 publication.
- Wu M et al. A Prognostic Model of Differentiated Thyroid Cancer Based on Up-Regulated Glycolysis-Related Genes. Front Endocrinol (Lausanne) 13:775278 (2022). PubMed: 35528004