Overview

  • Product name

    ADWX-1, KV1.3 channel blocker
  • Description

    Highly potent, selective KV1.3 channel blocker
  • Biological description

    Highly potent, selective KV1.3 channel blocker (IC50 values = 0.0019 nM and 0.65 nM for KV1.3 and KV1.1, respectively). Inhibits CD4+ CCR7- T cell activation. Shows immunomodulatory effects in vivo.
  • Purity

    > 98%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Li Z  et al. Selective inhibition of CCR7(-) effector memory T cell activation by a novel peptide targeting Kv1.3 channel in a rat experimental autoimmune encephalomyelitis model. J Biol Chem 287:29479-94 (2012). Read more (PubMed: 22761436) »
  • Han S  et al. Structural basis of a potent peptide inhibitor designed for Kv1.3 channel, a therapeutic target of autoimmune disease. J Biol Chem 283:19058-65 (2008). Read more (PubMed: 18480054) »
  • Yin SJ  et al. Different residues in channel turret determining the selectivity of ADWX-1 inhibitor peptide between Kv1.1 and Kv1.3 channels. J Proteome Res 7:4890-7 (2008). Read more (PubMed: 18937510) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145529.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up