AEBSF hydrochloride, serine protease inhibitor (ab141403)

Overview

  • Product name

    AEBSF hydrochloride, serine protease inhibitor
  • Description

    Broad spectrum, irreversible serine protease inhibitor
  • Alternative names

    • 4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride
    • 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
    • AEBSF HCl
    • Pefabloc SC
    • Pefabloc®SC
    see all
  • Biological description

    Broad spectrum, irreversible serine protease inhibitor. Inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin and trypsin. Stable, non-toxic alternative to PMSF (ab141302).

  • Purity

    > 97%
  • CAS Number

    30827-99-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
  • Molecular weight

    239.69
  • Molecular formula

    C8H10FNO2S.HCl
  • PubChem identifier

    186136
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Unstable; make up solutions fresh and use immediately.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC=C1CCN)S(=O)(=O)F.Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Seto T  et al. SLPI prevents cytokine release in mite protease-exposed conjunctival epithelial cells. Biochem Biophys Res Commun 379:681-5 (2009). Read more (PubMed: 19103172) »
  • Solovyan VT & Keski-Oja J Proteolytic activation of latent TGF-beta precedes caspase-3 activation and enhances apoptotic death of lung epithelial cells. J Cell Physiol 207:445-53 (2006). Read more (PubMed: 16447253) »
  • Diatchuk V  et al. Inhibition of NADPH oxidase activation by 4-(2-aminoethyl)-benzenesulfonyl fluoride and related compounds. J Biol Chem 272:13292-301 (1997). Read more (PubMed: 9148950) »
  • Nakabo Y & Pabst MJ Lysis of leukemic cells by human macrophages: inhibition by 4-(2-aminoethyl)-benzenesulfonyl fluoride (AEBSF), a serine protease inhibitor. J Leukoc Biol 60:328-36 (1996). Read more (PubMed: 8830789) »
  • Citron M  et al. Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. Neuron 17:171-9 (1996). Read more (PubMed: 8755488) »

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