Aeroplysinin (Aeroplysinin-1), antiangiogenic agent (ab142685)

Overview

  • Product name

    Aeroplysinin (Aeroplysinin-1), antiangiogenic agent
  • Description

    Potent antiangiogenic agent
  • Alternative names

    • Aeroplysinin-1
  • Biological description

    Potent antiangiogenic agent. Inhibits COX-2 expression. Selectivity for endothelial cells. Able to induce apoptosis via capsase activation, chromatin condensation and nuclear fragmentation. Antibiotic and cytotoxic effects (IC50 = 3 μm) and displays a wide-spectrum antitumor activity. Active in vivo.
  • Purity

    > 96%
  • CAS Number

    28656-91-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(1S,6R)-3,5-Dibromo-1,6-dihydroxy-4-methoxycyclohexa-2,4-dien-1-yl]acetonitrile
  • Molecular weight

    338.98
  • Molecular formula

    C9H9Br2NO3
  • PubChem identifier

    100308
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=C(C(C(C=C1Br)(CC#N)O)O)Br
  • Source

    Aplysina aerophoba

  • Research areas

References

This product has been referenced in:

  • Martínez-Poveda B  et al. The brominated compound aeroplysinin-1 inhibits proliferation and the expression of key pro- inflammatory molecules in human endothelial and monocyte cells. PLoS One 8:e55203 (2013). Read more (PubMed: 23383109) »
  • Martínez-Poveda B  et al. The antiangiogenic compound aeroplysinin-1 induces apoptosis in endothelial cells by activating the mitochondrial pathway. Mar Drugs 10:2033-46 (2012). Read more (PubMed: 23118719) »
  • Teeyapant R  et al. Antibiotic and cytotoxic activity of brominated compounds from the marine sponge Verongia aerophoba. Z Naturforsch C 48:939-45 (0). Read more (PubMed: 8297426) »

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