Key features and details
- Mouse monoclonal [HAF10 10D3/8] to AF10
- Suitable for: WB, ELISA, IP
- Reacts with: Human
- Isotype: IgG2a
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferConstituent: PBS
Concentration information loading...
PurityProtein A/G purified
Clone numberHAF10 10D3/8
Our Abpromise guarantee covers the use of ab16969 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent dilution. Predicted molecular weight: 110 kDa.|
|ELISA||Use at an assay dependent dilution.|
|IP||Use at an assay dependent dilution.|
FunctionProbably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA.
Tissue specificityExpressed abundantly in testis.
Involvement in diseaseA chromosomal aberration involving MLLT10 is associated with acute leukemias. Translocation t(10;11)(p12;q23) with KMT2A/MLL1. The result is a rogue activator protein.
A chromosomal aberration involving MLLT10 is associated with diffuse histiocytic lymphomas. Translocation t(10;11)(p13;q14) with PICALM.
Sequence similaritiesContains 1 C2HC pre-PHD-type zinc finger.
Contains 2 PHD-type zinc fingers.
- Information by UniProt
- AF 10 antibody
- AF10 antibody
- AF10_HUMAN antibody
ab16969 has been referenced in 1 publication.
- Bitoun E et al. The mixed-lineage leukemia fusion partner AF4 stimulates RNA polymerase II transcriptional elongation and mediates coordinated chromatin remodeling. Hum Mol Genet 16:92-106 (2007). WB ; Mouse . PubMed: 17135274