Key features and details
- Antagonist for human type I interleukin receptor
- CAS Number: 185413-30-3
- Soluble in 3:1 water/acetonitrile to 1 mg/ml
- Form / State: Solid
- Source: Synthetic
Product nameAF12198, human type I interleukin receptor antagonist
DescriptionAntagonist for human type I interleukin receptor
Potent and selective antagonist peptide for human type I interleukin-1 receptor (IL1R1) (IC50 values are 8 nM, > 6.7 µM and > 200 µM for hIL1R1,hIL1R2 and hIL1R1, respectively). Blocks IL-1-induced expression of ICAM-1 and reduces IL-1β-induced IL-6 and IL-8 production. Also exhibits anti-inflammatory activity. Active in vivo.
SequenceFEWTPGWYQXYALPL (Modifications: N-terminal acetyl; C-terminal amide; X-10 = Aze)
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in 3:1 water/acetonitrile to 1 mg/ml
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141983 has not yet been referenced specifically in any publications.