AF12198, human type I interleukin receptor antagonist (ab141983)

Overview

  • Product name

    AF12198, human type I interleukin receptor antagonist
  • Description

    Antagonist for human type I interleukin receptor
  • Biological description

    Potent and selective antagonist peptide for human type I interleukin-1 receptor (IL1R1) (IC50 values are 8 nM, > 6.7 µM and > 200 µM for hIL1R1,hIL1R2 and hIL1R1, respectively). Blocks IL-1-induced expression of ICAM-1 and reduces IL-1β-induced IL-6 and IL-8 production. Also exhibits anti-inflammatory activity. Active in vivo.
  • CAS Number

    185413-30-3
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    1895.14
  • Molecular formula

    C96H123N19O22
  • Sequence

    FEWTPGWYQXYALPL (Modifications: N-terminal acetyl; C-terminal amide; X-10 = Aze)
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 3:1 water/acetonitrile to 1 mg/ml
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H]([C@@H](C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](Cc2c[nH]c3c2cccc3)C(=O)N[C@@H](Cc4ccc(cc4)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N5CCC5C(=O)N[C@@H](Cc6ccc(cc6)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N7CCC[C@H]7C(=O)N[C@@H](CC(C)C)C(=O)N)NC(=O)[C@H](Cc8c[nH]c9c8cccc9)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)C)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Sim YB  et al. Interleukin-1ß (IL-1ß) increases pain behavior and the blood glucose level: possible involvement of sympathetic nervous system. Pharmacol Biochem Behav 102:170-6 (2012). Read more (PubMed: 22548833) »
  • Lin CH  et al. Interleukin-1ß expression is required for lysophosphatidic Acid-induced lymphangiogenesis in human umbilical vein endothelial cells. Int J Inflam 2011:351010 (2011). Read more (PubMed: 21151531) »
  • Aimbire F  et al. Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1beta levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation 31:189-97 (2008). Read more (PubMed: 18421573) »
  • Akeson AL  et al. AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J Biol Chem 271:30517-23 (1996). Read more (PubMed: 8940020) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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