Product nameAfatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor
DescriptionPotent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor
Biological descriptionPotent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor (IC50 values are 0.5, 0.4, 10 and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 respectively). Shows antitumor effects in vivo. Orally active.
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 25 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
This product has been referenced in:
- Huber K et al. A rapid ex vivo tissue model for optimising drug detection and ionisation in MALDI imaging studies. Histochem Cell Biol : (2014). Read more (PubMed: 24824474) »
- Giaccone G & Wang Y Strategies for overcoming resistance to EGFR family tyrosine kinase inhibitors. Cancer Treat Rev 37:456-64 (2011). Read more (PubMed: 21367530) »
- Eccles SA The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology. Int J Dev Biol 55:685-96 (2011). Read more (PubMed: 22161825) »