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    afatinib-bibw-2992-her2erbb-2-and-egfr-kinase-inhibitor-ab142018.pdf

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Cell Biology Cell Cycle Kinases/Phosphatases Other
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Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor (ab142018)

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Chemical Structure - Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor (ab142018)

    Key features and details

    • Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor
    • CAS Number: 439081-18-2
    • Purity: > 98%
    • Soluble in ethanol to 25 mM and in DMSO to 100 mM

    • Form / State: Powder
    • Source: Synthetic

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    Overview

    • Product name

      Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor
    • Description

      Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor
    • Biological description

      Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor (IC50 values are 0.5, 0.4, 10 and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 respectively). Shows antitumor effects in vivo. Orally active.

    • Purity

      > 98%
    • CAS Number

      439081-18-2
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      (S,E)-N-(4-(3-Chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

    • Molecular weight

      485.94
    • Molecular formula

      C24H25ClFN5O3
    • PubChem identifier

      10184653
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in ethanol to 25 mM and in DMSO to 100 mM

    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4
    • Source

      Synthetic

    • Research areas

      • Cell Biology
      • Cell Cycle
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      • Cell Cycle Inhibitors
      • p53
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      • Transcription
      • Cancer susceptibility
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      • Transcription
      • Other factors
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      • Cell cycle
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      • Secreted Molecules
      • Other secreted molecules
      • Cancer
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      • Protein phosphorylation
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    Images

    • Chemical Structure - Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor (ab142018)
      Chemical Structure - Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor (ab142018)
      2D chemical structure image of ab142018, Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor

    Protocols

    To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab142018? Please let us know so that we can cite the reference in this datasheet.

    ab142018 has been referenced in 1 publication.

    • Shen CH  et al. ZNRF1 Mediates Epidermal Growth Factor Receptor Ubiquitination to Control Receptor Lysosomal Trafficking and Degradation. Front Cell Dev Biol 9:642625 (2021). PubMed: 33996800

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