Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor (ab142018)

Overview

  • Product name

    Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor
  • Description

    Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor
  • Biological description

    Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor (IC50 values are 0.5, 0.4, 10 and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 respectively). Shows antitumor effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    439081-18-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Huber K  et al. A rapid ex vivo tissue model for optimising drug detection and ionisation in MALDI imaging studies. Histochem Cell Biol : (2014). Read more (PubMed: 24824474) »
  • Giaccone G & Wang Y Strategies for overcoming resistance to EGFR family tyrosine kinase inhibitors. Cancer Treat Rev 37:456-64 (2011). Read more (PubMed: 21367530) »
  • Eccles SA The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology. Int J Dev Biol 55:685-96 (2011). Read more (PubMed: 22161825) »

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