Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor (ab142018)
- Datasheet
- References
Overview
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Product name
Afatinib (BIBW 2992), Her2/ErbB 2 and EGFR kinase inhibitor -
Description
Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor -
Biological description
Potent, irreversible Her2/ErbB 2 and EGFR kinase inhibitor (IC50 values are 0.5, 0.4, 10 and 14 nM for EGFR(wt), EGFR(L858R), EGFR(L858R/T790M) and HER2 respectively). Shows antitumor effects in vivo. Orally active. -
Purity
> 99% -
CAS Number
439081-18-2 -
Chemical structure
Properties
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Chemical name
(S,E)-N-(4-(3-Chloro-4-fluorophenylamino)-7-(tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide -
Molecular weight
485.94 -
Molecular formula
C24H25ClFN5O3 -
PubChem identifier
10184653 -
Storage instructions
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in ethanol to 25 mM and in DMSO to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4 -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Huber K et al. A rapid ex vivo tissue model for optimising drug detection and ionisation in MALDI imaging studies. Histochem Cell Biol : (2014). Read more (PubMed: 24824474) »
- Giaccone G & Wang Y Strategies for overcoming resistance to EGFR family tyrosine kinase inhibitors. Cancer Treat Rev 37:456-64 (2011). Read more (PubMed: 21367530) »
- Eccles SA The epidermal growth factor receptor/Erb-B/HER family in normal and malignant breast biology. Int J Dev Biol 55:685-96 (2011). Read more (PubMed: 22161825) »
