AFC (7-Amino-4-trifluoromethylcoumarin), Fluorescent marker (ab145587)

Overview

  • Product name

    AFC (7-Amino-4-trifluoromethylcoumarin), Fluorescent marker
  • Description

    Fluorescent marker. Substrate for fluorogenic enzyme assays.
  • Alternative names

    • 7-Amino-4-trifluoromethylcoumarin
  • Biological description

    Fluorescent marker. Substrate for fluorogenic enzyme assays. Calibration standard.

  • Purity

    > 99%
  • CAS Number

    53518-15-3
  • Chemical structure

    Chemical Structure

Properties

  • Excitation

    380nm
  • Emission

    460nm
  • Chemical name

    7-Amino-4-(trifluoromethyl)chromen-2-one
  • Molecular weight

    229.16
  • Molecular formula

    C10H6F3NO2
  • PubChem identifier

    100641
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC2=C(C=C1N)OC(=O)C=C2C(F)(F)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kawasaki T & Kamijo S Inhibition of aggregation of amyloid ß42 by arginine-containing small compounds. Biosci Biotechnol Biochem 76:762-6 (2012). Read more (PubMed: 22484947) »
  • Richards GP & Watson MA Fluorogenic Membrane Overlays to Enumerate Total and Fecal Escherichia coli and Total Vibrionaceae in Shellfish and Seawater. Int J Microbiol 2010:910486 (2010). Read more (PubMed: 20396663) »
  • Foley JD  et al. Temporal regulation of VEID-7-amino-4-trifluoromethylcoumarin cleavage activity and caspase-6 correlates with organelle loss during lens development. J Biol Chem 279:32142-50 (2004). Read more (PubMed: 15161922) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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