Overview

  • Product name

    AG-1024, IGF-1 receptor inhibitor
  • Description

    Selective IGF-1 receptor inhibitor. Potent antiproliferative agent.
  • Biological description

    Selective IGF-1 receptor inhibitor (IC50 = 7 μM). Potent antiproliferative agent (IC50 = 50 nM, melanoma cells). Decreases bcl-2 and phospho-Akt1. Increases Bax, p53 and p21. Induces apoptosis and shows antiproliferative effects. Shows antitumor effects in vivo.
  • Purity

    > 99%
  • CAS Number

    65678-07-1
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Deutsch E  et al. Tyrosine kinase inhibitor AG1024 exerts antileukaemic effects on STI571-resistant Bcr-Abl expressing cells and decreases AKT phosphorylation. Br J Cancer 91:1735-41 (2004). Read more (PubMed: 15494718) »
  • von Willebrand M  et al. The tyrphostin AG1024 accelerates the degradation of phosphorylated forms of retinoblastoma protein (pRb) and restores pRb tumor suppressive function in melanoma cells. Cancer Res 63:1420-9 (2003). Read more (PubMed: 12649208) »
  • Párrizas M  et al. Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins. Endocrinology 138:1427-33 (1997). Read more (PubMed: 9075698) »

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