Key features and details
- Tyrosine kinase inhibitor
- CAS Number: 118409-62-4
- Purity: > 98%
- Soluble in DMSO to 100 mM and in ethanol to 10 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Product nameAG-126, Tyrosine kinase inhibitor
DescriptionTyrosine kinase inhibitor
Biological descriptionTyrosine kinase inhibitor. Inhibits glucocorticoid induced COX-2 activity (IC50 = 15 μM). Blocks lipopolysaccharide (LPS) induced TNFα synthesis and tyrosine phosphorylation of ERK2. Cell-permeable. Shows anti-inflammtory activity. Active in vivo.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 10 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141572 has not yet been referenced specifically in any publications.