Overview

  • Product name

    AG 1296, protein tyrosine kinase inhibitor
  • Description

    Potent specific PDGF receptor tyrosine kinase inhibitor
  • Biological description

    Potent specific platelet-derived growth factor (PDGF) receptor tyrosine kinase inhibitor (IC50 values are 1.0 μM and 0.8 μM at PDGF α and β-receptors respectively). Cell-permeable.
  • Purity

    > 99%
  • CAS Number

    146535-11-7
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Strutz F  et al. TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2). Kidney Int 59:579-92 (2001). Read more (PubMed: 11168939) »
  • Kovalenko M  et al. Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296. Biochemistry 36:6260-9 (1997). Read more (PubMed: 9174341) »
  • Kovalenko M  et al. Selective platelet-derived growth factor receptor kinase blockers reverse sis-transformation. Cancer Res 54:6106-14 (1994). Read more (PubMed: 7954456) »

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