Overview

  • Product name

    AG-370, PDGFR tyrosine kinase inhibitor
  • Description

    Selective PDGFR tyrosine kinase inhibitor
  • Biological description

    Selective platelet-derived growth factor receptor (PDGFR) kinase inhibitor (IC50 = 20 μM). Weak epidermal growth factor receptor (EGFR) inhibitor (IC50 = 820 μM). Blocks proliferative effect of PDGF.
  • Purity

    > 99%
  • CAS Number

    134036-53-6
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Gazit A  et al. Tyrphostins. 6. Dimeric benzylidenemalononitrile tyrophostins: potent inhibitors of EGF receptor tyrosine kinase in vitro. J Med Chem 39:4905-11 (1996). Read more (PubMed: 8960549) »
  • Bryckaert MC  et al. Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins. Exp Cell Res 199:255-61 (1992). Read more (PubMed: 1312007) »
  • Levitzki A  et al. Inhibition of protein-tyrosine kinases by tyrphostins. Methods Enzymol 201:347-61 (1991). Read more (PubMed: 1658552) »
  • Levitzki A & Gilon C Tyrphostins as molecular tools and potential antiproliferative drugs. Trends Pharmacol Sci 12:171-4 (1991). Read more (PubMed: 1862529) »
  • Gazit A  et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem 32:2344-52 (1989). Read more (PubMed: 2552117) »

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