Overview

  • Product name

    AG 825, ErbB2 inhibitor
  • Description

    Selective ErbB2 inhibitor
  • Biological description

    Selective ErbB2 inhibitor (IC50 values are 0.15 and 19 μM at ErbB2 and ErbB1, respectively). Suppresses IL-6 induced STAT3 activation. Shows antiproliferative effects. Shows antitumor effects in vivo.
  • Purity

    > 96%
  • CAS Number

    149092-50-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    3-[3-[(2-Benzothiazolylthio)methyl]-4-hydroxy-5-methoxyphenyl]-2-cyano-2-propenamide
  • Molecular weight

    397.47
  • Molecular formula

    C19H15N3O3S2
  • PubChem identifier

    6091659
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC(=CC(=C1O)CSC2=NC3=CC=CC=C3S2)C=C(C#N)C(=O)N
  • Source

    Synthetic

References

This product has been referenced in:

  • Brechbuhl HM  et al. Epidermal growth factor receptor activity is necessary for mouse basal cell proliferation. Am J Physiol Lung Cell Mol Physiol 307:L800-10 (2014). Read more (PubMed: 25217659) »
  • Lee HK  et al. Tyrphostin ErbB2 Inhibitors AG825 and AG879 Have Non-specific Suppressive Effects on gp130/ STAT3 Signaling. Korean J Physiol Pharmacol 12:281-6 (2008). Read more (PubMed: 19967068) »
  • Lehnes K  et al. The effect of estradiol on in vivo tumorigenesis is modulated by the human epidermal growth factor receptor 2/phosphatidylinositol 3-kinase/Akt1 pathway. Endocrinology 148:1171-80 (2007). Read more (PubMed: 17138652) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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