Overview

  • Product name

  • Description

    Rabbit polyclonal to Aggrecan
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat
    Predicted to work with: Human
  • Immunogen

    Synthetic peptide within Human Aggrecan aa 130-190 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: P16112

  • Positive control

    • IHC-P - Rat synovial tissue; Mouse embryo tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab216965 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

Target

  • Relevance

    Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.
  • Cellular localization

    Secreted; extracellular matrix.
  • Database links

  • Alternative names

    • ACAN antibody
    • AGC 1 antibody
    • AGC1 antibody
    • AGCAN antibody
    • Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122) antibody
    • Aggrecan 1 antibody
    • Aggrecan core protein antibody
    • Aggrecan proteoglycan antibody
    • Aggrecan structural proteoglycan of cartilage antibody
    • Aggrecan1 antibody
    • ATEGQV antibody
    • Cartilage specific proteoglycan core protein antibody
    • Chondroitin sulfate proteoglycan 1 antibody
    • Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122 antibody
    • Chondroitin sulfate proteoglycan core protein 1 antibody
    • CSPG 1 antibody
    • CSPG1 antibody
    • CSPGCP antibody
    • JSCATE antibody
    • Large aggregating proteoglycan antibody
    • mcspg antibody
    • mgsk16 antibody
    • MSK 16 antibody
    • MSK16 antibody
    • SEDK antibody
    see all

Images

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Rat synovial tissue labeling Aggrecan with ab216965 at 1/100 dilution, followed by secondary detection and DAB staining.

  • Immunohistochemical analysis of formalin fixed, paraffin embedded Mouse embryo tissue labeling Aggrecan with ab216965 at 1/200 dilution, followed by secondary antibody detection and DAB staining.

References

ab216965 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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