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Signal Transduction Cytoskeleton / ECM Extracellular Matrix ECM Proteins Aggrecan
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Anti-Aggrecan antibody - C-terminal (ab140691)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Aggrecan antibody - C-terminal (ab140691)

    Key features and details

    • Rabbit polyclonal to Aggrecan - C-terminal
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Product image
    Recombinant Human Aggrecan protein (ab114254)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-Aggrecan antibody - C-terminal
      See all Aggrecan primary antibodies
    • Description

      Rabbit polyclonal to Aggrecan - C-terminal
    • Host species

      Rabbit
    • Specificity

      BLAST analysis of the peptide immunogen showed no homology with other human proteins, except REG1A (50%).
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Horse, Hamster, Monkey, Gorilla, Opossum, Common marmoset, Platypus
    • Immunogen

      16 amino acid synthetic peptide from the C terminal region of Human Aggrecan (NP_037359.2).

    • Positive control

      • Human cartilage tissue.
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    • Storage buffer

      Preservative: 0.1% Sodium azide
      Constituent: 99% PBS
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Cytoskeleton / ECM
      • Extracellular Matrix
      • ECM Proteins
      • Aggrecan
      • Stem Cells
      • Mesenchymal Stem Cells
      • Chondrogenesis

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Recombinant Protein

      • Recombinant Human Aggrecan protein (ab114254)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab140691 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
    Notes
    IHC-P
    Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

    Target

    • Relevance

      Aggrecan is a member of a family of large, aggregating proteoglycans (also including versican, brevican and neurocan) which is found in articular cartilage. Aggrecan is composed of three major domains: G1, G2, and G3. Between the G1 and G2 domains there is an interglobulin region (IGD). The IGD region is the major site of cleavage by specific proteases like metalloproteinases (MMPs) and aggrecanase. Aggrecan cleavage has been associated with a number of degenerative diseases including rheumatoid arthritis and osteoarthritis. There is evidence that this family of proteoglycans modulates cell adhesion, migration, and axonal outgrowth in the CNS.
    • Cellular localization

      Secreted; extracellular matrix.
    • Database links

      • Entrez Gene: 176 Human
      • Entrez Gene: 11595 Mouse
      • Entrez Gene: 58968 Rat
      • Omim: 155760 Human
      • SwissProt: P16112 Human
      • SwissProt: Q61282 Mouse
      • SwissProt: P07897 Rat
      • Alternative names

        • ACAN antibody
        • AGC 1 antibody
        • AGC1 antibody
        • AGCAN antibody
        • Aggrecan 1 (chondroitin sulfate proteoglycan 1, large aggregating proteoglycan, antigen identified by monoclonal antibody A0122) antibody
        • Aggrecan 1 antibody
        • Aggrecan core protein antibody
        • Aggrecan proteoglycan antibody
        • Aggrecan structural proteoglycan of cartilage antibody
        • Aggrecan1 antibody
        • ATEGQV antibody
        • Cartilage specific proteoglycan core protein antibody
        • Chondroitin sulfate proteoglycan 1 antibody
        • Chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122 antibody
        • Chondroitin sulfate proteoglycan core protein 1 antibody
        • CSPG 1 antibody
        • CSPG1 antibody
        • CSPGCP antibody
        • JSCATE antibody
        • Large aggregating proteoglycan antibody
        • mcspg antibody
        • mgsk16 antibody
        • MSK 16 antibody
        • MSK16 antibody
        • SEDK antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Aggrecan antibody - C-terminal (ab140691)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Aggrecan antibody - C-terminal (ab140691)
        Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human cartilage tissue (after heat induced antigen retrieval) labelling Aggrecan with ab140691 at 10 µg/ml.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (0)

      Publishing research using ab140691? Please let us know so that we can cite the reference in this datasheet.

      ab140691 has not yet been referenced specifically in any publications.

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