Anti-Aggrecan ARGxx antibody [BC-3] (ab3773)

Publishing research using ab3773? Please let us know so that we can cite the reference in this datasheet.

ab3773 has been referenced in 23 publications.

  • Shen L  et al. Overexpression of growth and differentiation factor-5 inhibits inflammatory factors released by intervertebral disc cells. Exp Ther Med 15:3603-3608 (2018). PubMed: 29545889
  • Lu W  et al. CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci 17:N/A (2016). Rat . PubMed: 27690009
  • Kumar S  et al. Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice. Sci Rep 6:31130 (2016). IHC-Fr ; Mouse . PubMed: 27491335
  • Li P  et al. Surgical removal and controlled trypsinization of the outer annulus fibrosus improves the bioactivity of the nucleus pulposus in a disc bioreactor culture. BMC Musculoskelet Disord 17:133 (2016). PubMed: 27000557
  • Thompson CL  et al. Lithium chloride prevents interleukin-1ß induced cartilage degradation and loss of mechanical properties. J Orthop Res 33:1552-9 (2015). PubMed: 26174175
  • Guha Thakurta S  et al. Growth factor and ultrasound-assisted bioreactor synergism for human mesenchymal stem cell chondrogenesis. J Tissue Eng 6:2041731414566529 (2015). WB ; Human . PubMed: 25610590
  • Hasegawa A  et al. Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis. Arthritis Res Ther 15:R29 (2013). IHC-P ; Human . PubMed: 23406989
  • Zhang E  et al. Aggrecanases in the human synovial fluid at different stages of osteoarthritis. Clin Rheumatol 32:797-803 (2013). PubMed: 23370724
  • Tsirimonaki E  et al. PKCe Signalling Activates ERK1/2, and Regulates Aggrecan, ADAMTS5, and miR377 Gene Expression in Human Nucleus Pulposus Cells. PLoS One 8:e82045 (2013). WB, ICC/IF ; Human . PubMed: 24312401
  • Wang L  et al. Effects of cleavage by a disintegrin and metalloproteinase with thrombospondin motifs-4 on gene expression and protein content of versican and aggrecan in the digital laminae of horses with starch gruel-induced laminitis. Am J Vet Res 73:1047-56 (2012). PubMed: 22738057
  • Funck-Brentano T  et al. Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism. PLoS One 7:e33543 (2012). WB ; Human . PubMed: 22432033
  • Wang J  et al. TNF-a and IL-1ß Promote a Disintegrin-like and Metalloprotease with Thrombospondin Type I Motif-5-mediated Aggrecan Degradation through Syndecan-4 in Intervertebral Disc. J Biol Chem 286:39738-49 (2011). WB ; Human . PubMed: 21949132
  • Torzilli PA  et al. Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage. Osteoarthritis Cartilage 18:97-105 (2010). PubMed: 19747586
  • Sondergaard BC  et al. MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. Osteoarthritis Cartilage 18:279-88 (2010). Sandwich ELISA ; Cow . PubMed: 19932675
  • Madsen SH  et al. Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo. Biomarkers 15:266-76 (2010). PubMed: 20039789
  • Lee CH  et al. Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study. Lancet 376:440-8 (2010). PubMed: 20692530
  • Rousseau JC  et al. Patients with rheumatoid arthritis have an altered circulatory aggrecan profile. BMC Musculoskelet Disord 9:74 (2008). WB ; Human . PubMed: 18507823
  • Karsdal MA  et al. Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity. Arthritis Res Ther 10:R63 (2008). ELISA ; Cow . PubMed: 18513402
  • Karsdal MA  et al. Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation. Arthritis Rheum 56:1549-58 (2007). PubMed: 17469134
  • Shao X & Hunter CJ Developing an alginate/chitosan hybrid fiber scaffold for annulus fibrosus cells. J Biomed Mater Res A 82:701-10 (2007). PubMed: 17326226
  • Llamazares M  et al. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. J Cell Sci 120:3544-52 (2007). WB ; Dog . PubMed: 17895370
  • Molecular Approaches to Osteoarthritis Research. Abstracts of the Kennedy Institute of Rheumatology Symposium, London, United Kingdom, April 18-20, 2004. Scand J Rheumatol Suppl :1-41 (2005). PubMed: 15864865
  • Innes JF  et al. Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early- and late-stage osteoarthritis. Am J Vet Res 66:1679-85 (2005). PubMed: 16273897


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