Agomelatine, MT1/MT2 agonist and 5-HT2C antagonist (ab142476)

Overview

  • Product name

    Agomelatine, MT1/MT2 agonist and 5-HT2C antagonist
  • Description

    Potent MT1/MT2 agonist and 5-HT2C antagonist
  • Biological description

    Potent MT1/MT2 agonist (Ki values are 0.1 and 0.12 nM, respectively). 5-HT2C antagonist (IC50 = 270 nM). Shows antidepressant effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    138112-76-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Ladurelle N  et al. Agomelatine (S20098) modulates the expression of cytoskeletal microtubular proteins, synaptic markers and BDNF in the rat hippocampus, amygdala and PFC. Psychopharmacology (Berl) 221:493-509 (2012). Read more (PubMed: 22160164) »
  • Hardeland R & Poeggeler B Melatonin and synthetic melatonergic agonists: actions and metabolism in the central nervous system. Cent Nerv Syst Agents Med Chem 12:189-216 (2012). Read more (PubMed: 22640220) »
  • Reagan LP  et al. The antidepressant agomelatine inhibits stress-mediated changes in amino acid efflux in the rat hippocampus and amygdala. Brain Res 1466:91-8 (2012). Read more (PubMed: 22647752) »

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