Key features and details
- Rabbit polyclonal to AGRP
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-AGRP antibody
See all AGRP primary antibodies
DescriptionRabbit polyclonal to AGRP
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Synthetic peptide from internal sequence residues of Human AGRP (NM_001138.1).
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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FormLyophilized:Reconstitute with 200ul distilled H2O. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituent: 1% BSA
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab113481 is purified by a peptide affinity column.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Fatty acids
Our Abpromise guarantee covers the use of ab113481 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 14 kDa.|
FunctionPlays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
Tissue specificityExpressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
Involvement in diseaseGenetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
Sequence similaritiesContains 1 agouti domain.
DomainThe presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
Cellular localizationSecreted. Golgi apparatus lumen.
- Information by UniProt
- Agouti related neuropeptide antibody
- Agouti Related Protein Homolog antibody
- Agouti-related protein antibody
ab113481 has been referenced in 2 publications.
- Imbernon M et al. Hypothalamic KLF4 mediates leptin's effects on food intake via AgRP. Mol Metab 3:441-51 (2014). IHC-P ; Rat . PubMed: 24944903
- Lopez R et al. Hyperglycemia enhances the proliferation of non-tumorigenic and malignant mammary epithelial cells through increased leptin/IGF1R signaling and activation of AKT/mTOR. PLoS One 8:e79708 (2013). WB ; Human . PubMed: 24260287