Anti-AGRP antibody (ab199126)
Key features and details
- Rabbit polyclonal to AGRP
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-AGRP antibody
See all AGRP primary antibodies -
Description
Rabbit polyclonal to AGRP -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human AGRP (internal sequence). (NP_001129).
Database link: O00253 -
Positive control
- Human gastric cancer and colon cancer tissues.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab199126 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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IHC-P |
1/25 - 1/100.
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Notes |
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IHC-P
1/25 - 1/100. |
Target
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Function
Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R. -
Tissue specificity
Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney. -
Involvement in disease
Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. -
Sequence similarities
Contains 1 agouti domain. -
Domain
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. -
Cellular localization
Secreted. Golgi apparatus lumen. - Information by UniProt
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Database links
- Entrez Gene: 181 Human
- Omim: 602311 Human
- SwissProt: O00253 Human
- Unigene: 104633 Human
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Alternative names
- Agouti related neuropeptide antibody
- Agouti Related Protein Homolog antibody
- Agouti-related protein antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab199126 has not yet been referenced specifically in any publications.