Overview

  • Product name

  • Description

    Rabbit polyclonal to AGRP
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human AGRP (internal sequence). (NP_001129).
    Database link: O00253

  • Positive control

    • Human gastric cancer and colon cancer tissues.

Properties

Applications

Our Abpromise guarantee covers the use of ab199126 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/25 - 1/100.

Target

  • Function

    Plays a role in weight homeostasis. Plays a role in the central control of feeding. Reduces food intake. Inhibits cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Acts primarily on MC3R and MC4R. Has very low activity with MC5R.
  • Tissue specificity

    Expressed primarily in the adrenal gland, subthalamic nucleus, and hypothalamus, with a lower level of expression occurring in testis, lung, and kidney.
  • Involvement in disease

    Genetic variations in AGRP may be a cause of obesity (OBESITY) [MIM:601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
  • Sequence similarities

    Contains 1 agouti domain.
  • Domain

    The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.
  • Cellular localization

    Secreted. Golgi apparatus lumen.
  • Information by UniProt
  • Database links

  • Alternative names

    • Agouti related neuropeptide antibody
    • Agouti Related Protein Homolog antibody
    • Agouti-related protein antibody
    • Agrp antibody
    • AGRP_HUMAN antibody
    • AGRT antibody
    • ART antibody
    • ASIP2 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling AGRP with ab199126 at 1/20 dilution.

  • Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue labeling AGRP with ab199126 at 1/20 dilution.

References

ab199126 has not yet been referenced specifically in any publications.

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