Product nameAnti-AHRR antibody
See all AHRR primary antibodies
DescriptionRabbit polyclonal to AHRR
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide from the N terminal region of Human AHRR.
- Human fetal testis tissue. Human fetal lung, testis and spleen lysates.
FormLyophilised:Reconstitute with 200ul distilled H2O. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 1% BSA, PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab108518 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/1000 - 1/2000. Predicted molecular weight: 76 kDa.|
|IHC-P||1/100 - 1/500.|
FunctionMediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site.
Tissue specificityHighly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary.
Sequence similaritiesContains 1 basic helix-loop-helix (bHLH) domain.
Contains 1 PAS (PER-ARNT-SIM) domain.
Cellular localizationCytoplasm. Nucleus. Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
- Information by UniProt
- AHH antibody
- AhR repressor antibody
- AhRR antibody
All lanes : Anti-AHRR antibody (ab108518) at 1/1000 dilution
Lane 1 : Fetal testis lysate
Lane 2 : Fetal lung lysate
Lane 3 : Fetal spleen lysate
Predicted band size: 76 kDa
ab108518 at 1/100 dilution showing cytoplasmic and nuclear staining of AHRR in formalin-fixed, paraffin-embedded Human fetal testis by Immunohistochemistry.
ab108518 has been referenced in 3 publications.
- Silveira LTR et al. Protective effect of resveratrol on urogenital sinus and prostate development in rats exposed in utero to TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin). Reprod Toxicol N/A:N/A (2018). PubMed: 29935225
- Nakayama K et al. Influence of AHRR Pro189Ala polymorphism on kidney functions. Biosci Biotechnol Biochem 81:1120-1124 (2017). PubMed: 28485216
- Zhao LH et al. Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma. Nat Commun 7:12992 (2016). PubMed: 27703150