AICAR (Acadesine/AICA riboside) (aqueous solution), protein kinase activator (ab146594)

Overview

  • Product name

    AICAR (Acadesine/AICA riboside) (aqueous solution), protein kinase activator
  • Description

    Cell-permeable activator of AMP-activated protein kinase
  • Biological description

    Cell-permeable activator of AMP-activated protein kinase. Is taken up into cells by adenosine transporters and phosphorylated by adenosine kinase to the active nucleotide ZMP (5-aminoimidazole-4-carboxamide ribonucleoside), which mimics effects of AMP on the AMPK system. Active in vivo and in vitro.

    Also available as a solid (ab120358).
  • Purity

    > 98%
  • CAS Number

    2627-69-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Amino-1-[(2R,3S,4R,5R)-tetrahydro-3,4-dihydroxy-5-(hydroxymethyl)furan-2-yl]-1H-imidazole-4-carboxamide
  • Molecular weight

    258.23
  • Molecular formula

    C9H14N4O5
  • PubChem identifier

    17513
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Supplied in water (250 mM)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    NC(=O)c2ncn([C@@H]1O[C@H](CO)[C@H](O)[C@@H]1O)c2N
  • Source

    Synthetic

References

ab146594 has not yet been referenced specifically in any publications.

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