Overview

  • Product name

  • Description

    Rabbit polyclonal to AICDA
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Chimpanzee
  • Immunogen

    Recombinant fragment within Human AICDA aa 67-198. The exact sequence is proprietary.
    Database link: Q9GZX7

  • Positive control

    • K562, THP1 and HL60 whole cell lysates; SAS xenograft.

Properties

Applications

Our Abpromise guarantee covers the use of ab183618 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 23 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.
  • Tissue specificity

    Strongly expressed in lymph nodes and tonsils.
  • Involvement in disease

    Defects in AICDA are the cause of hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]; also known as hyper-IgM syndrome 2. HIGM2 is an autosomal recessive disorder characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.
  • Sequence similarities

    Belongs to the cytidine and deoxycytidylate deaminase family.
  • Information by UniProt
  • Database links

  • Alternative names

    • Activation induced cytidine deaminase antibody
    • Activation induced deaminase antibody
    • Activation-induced cytidine deaminase antibody
    • AICDA antibody
    • AICDA_HUMAN antibody
    • AID antibody
    • ARP 2 antibody
    • ARP2 antibody
    • CDA 2 antibody
    • CDA2 antibody
    • Cytidine aminohydrolase antibody
    • HIGM2 antibody
    • Integrated into Burkitt's lymphoma cell line Ramos antibody
    see all

Images

  • All lanes : Anti-AICDA antibody (ab183618) at 1/1000 dilution

    Lane 1 : K562 whole cell lysate
    Lane 2 : THP1 whole cell lysate
    Lane 3 : HL60 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 23 kDa



    12% SDS PAGE

  • Immunohistochemical analysis of paraffin embedded SAS xenograft labeling AICDA with ab183618 at 1/500 dilution.

References

ab183618 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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