Key features and details
- Rabbit polyclonal to AICDA
- Suitable for: WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-AICDA antibody
See all AICDA primary antibodies
DescriptionRabbit polyclonal to AICDA
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Chimpanzee
Recombinant fragment within Human AICDA aa 67-198. The exact sequence is proprietary.
Database link: Q9GZX7
- K562, THP1 and HL60 whole cell lysates; SAS xenograft.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 20% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab183618 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 23 kDa.|
|IHC-P||1/100 - 1/1000.|
FunctionRNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.
Tissue specificityStrongly expressed in lymph nodes and tonsils.
Involvement in diseaseDefects in AICDA are the cause of hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]; also known as hyper-IgM syndrome 2. HIGM2 is an autosomal recessive disorder characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.
Sequence similaritiesBelongs to the cytidine and deoxycytidylate deaminase family.
- Information by UniProt
- Activation induced cytidine deaminase antibody
- Activation induced deaminase antibody
- Activation-induced cytidine deaminase antibody
All lanes : Anti-AICDA antibody (ab183618) at 1/1000 dilution
Lane 1 : K562 whole cell lysate
Lane 2 : THP1 whole cell lysate
Lane 3 : HL60 whole cell lysate
Lysates/proteins at 30 µg per lane.
Predicted band size: 23 kDa
12% SDS PAGE
Immunohistochemical analysis of paraffin embedded SAS xenograft labeling AICDA with ab183618 at 1/500 dilution.
ab183618 has not yet been referenced specifically in any publications.