• Product name

  • Description

    Rabbit polyclonal to AICDA
  • Host species

  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    A 16 amino acid peptide from near N terminal residues of Human AICDA

  • Positive control

    • Human placenta lysate, Human liver lysate and lymph node tissue



Our Abpromise guarantee covers the use of ab93596 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/1000. Predicted molecular weight: 24 kDa.
IHC-P 1/100 - 1/500.
ICC/IF Use a concentration of 5 µg/ml.


  • Function

    RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.
  • Tissue specificity

    Strongly expressed in lymph nodes and tonsils.
  • Involvement in disease

    Defects in AICDA are the cause of hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]; also known as hyper-IgM syndrome 2. HIGM2 is an autosomal recessive disorder characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.
  • Sequence similarities

    Belongs to the cytidine and deoxycytidylate deaminase family.
  • Information by UniProt
  • Database links

  • Alternative names

    • Activation induced cytidine deaminase antibody
    • Activation induced deaminase antibody
    • Activation-induced cytidine deaminase antibody
    • AICDA antibody
    • AICDA_HUMAN antibody
    • AID antibody
    • ARP 2 antibody
    • ARP2 antibody
    • CDA 2 antibody
    • CDA2 antibody
    • Cytidine aminohydrolase antibody
    • HIGM2 antibody
    • Integrated into Burkitt's lymphoma cell line Ramos antibody
    see all


  • Immunohistochemical staining of formalin-fixed paraffin-embedded lymph node showing cytoplasmic staining with ab93596 at 1/100 dilution.
  • ICC/IF image of ab93596 stained HepG2 cells. The cells were 4% formaldehyde (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab93596, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899 Dylight 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.


This product has been referenced in:

  • Wilson JJ  et al. Enhancing the efficacy of glycolytic blockade in cancer cells via RAD51 inhibition. Cancer Biol Ther N/A:1-14 (2018). Read more (PubMed: 30183475) »
See 1 Publication for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A


Thank you for your enquiry and your interest in our products.

The price, the unit size, tested species, tested applications and other useful information can be found on the on-line datasheet.

www.abcam.com/ab93596- Anti-AICDA antibody

If you need any further assistance in the future, please do not hesitate to contact me.

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Thank you for contacting us.

Unfortunately we do not have any other WB image than the published one. Although the observed band does appear like 50 kDa but we can confirm that the expected and observed band size would be 25kDa. We would be removing this image form the datasheet.

If you would like to use this antibody in WB then I can give you 100% Abtrial discount for WB image - with the code, you can get a free antibody just by testing this ab in WB and by submitting WB image. Full terms and conditions can be found at the following link;


I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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