Anti-AIM2 antibody (ab93015)
Key features and details
- Rabbit polyclonal to AIM2
- Suitable for: ICC/IF, WB, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-AIM2 antibody
See all AIM2 primary antibodies -
Description
Rabbit polyclonal to AIM2 -
Host species
Rabbit -
Tested applications
Suitable for: ICC/IF, WB, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse -
Immunogen
Recombinant fragment, corresponding to amino acids 93-341 of Human AIM2 (NM_004833).
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Lyophilized:Reconstitute with 200ul distilled sterile water. Please note that if you receive this product in liquid form it has already been reconstituted as described and no further reconstitution is necessary. -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: PBS, 1% BSA -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab93015 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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ICC/IF |
Use at an assay dependent concentration.
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WB | (4) |
1/500 - 1/1000. Predicted molecular weight: 39 kDa.
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IHC-P | (1) |
1/100 - 1/500.
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Notes |
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ICC/IF
Use at an assay dependent concentration. |
WB
1/500 - 1/1000. Predicted molecular weight: 39 kDa. |
IHC-P
1/100 - 1/500. |
Target
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Function
Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. -
Tissue specificity
Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. -
Sequence similarities
Belongs to the HIN-200 family.
Contains 1 DAPIN domain.
Contains 1 HIN-200 domain. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 9447 Human
- Entrez Gene: 383619 Mouse
- Omim: 604578 Human
- SwissProt: O14862 Human
- SwissProt: Q91VJ1 Mouse
- Unigene: 281898 Human
- Unigene: 131453 Mouse
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Alternative names
- Absent in melanoma 2 antibody
- AIM 2 antibody
- Aim2 antibody
see all
Images
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All lanes : Anti-AIM2 antibody (ab93015) at 1/500 dilution
Lane 1 : EC-109 cell lysate
Lane 2 : HepG2 cell lysate
Predicted band size: 39 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of fetal spleen tissue sections labeling AIM2 with ab93015 at 1/100 dilution.
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Immunohistochemical staining of AIM2 in formalin fixed, paraffin embedded Human fetal tonsil showing nuclear staining with ab93015 at a dilution of 1/100.
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (36)
ab93015 has been referenced in 36 publications.
- Li Z et al. Activation of the NLRP3 inflammasome and elevation of interleukin-1β secretion in infection by sever fever with thrombocytopenia syndrome virus. Sci Rep 12:2573 (2022). PubMed: 35173184
- Zhao Q et al. The central role of a two-way positive feedback pathway in molecular targeted therapies-mediated pyroptosis in anaplastic thyroid cancer. Clin Transl Med 12:e727 (2022). PubMed: 35184413
- Zhang T et al. CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition. Cell Death Dis 13:167 (2022). PubMed: 35190532
- Harkin K et al. Wedelolactone Attenuates N-methyl-N-nitrosourea-Induced Retinal Neurodegeneration through Suppression of the AIM2/CASP11 Pathway. Biomedicines 10:N/A (2022). PubMed: 35203520
- Zheng Y et al. Probenecid-Blocked Pannexin-1 Channel Protects Against Early Brain Injury via Inhibiting Neuronal AIM2 Inflammasome Activation After Subarachnoid Hemorrhage. Front Neurol 13:854671 (2022). PubMed: 35401398